缬沙坦胶囊、厄贝沙坦片治疗糖尿病肾病患者106例临床观察

doi:10.3969/j.issn.1006-7795.2012.03.024

首都医科大学学报 ›› 2012, Vol. 33 ›› Issue (3): 399-402.doi: 10.3969/j.issn.1006-7795.2012.03.024

缬沙坦胶囊、厄贝沙坦片治疗糖尿病肾病患者106例临床观察

阿布都沙拉木·阿布都, 热衣木^1,2, 刘涛², 米尔班·阿不力克³, 木胡牙提⁴

1. 新疆医科大学高校6期研究生班,乌鲁木齐 830000;2. 新疆医科大学附属中医院老年病科,乌鲁木齐 830000;3. 新疆维吾尔自治区人民医院儿科研究所,乌鲁木齐 830001;4. 新疆医科大学第一附属医院普通心内科, 乌鲁木齐 830054

收稿日期:2012-03-25 修回日期:1900-01-01 出版日期:2012-06-21 发布日期:2012-06-21
通讯作者: 木胡牙提

Valsartan capsules, irbesartan tablets in the treatment of patients with diabetic nephropathy, clinical observation of 106 cases

Abudoushalamu·Abudoureyimu, LIU Tao^1,2, Mierban·Abulike², Muhuyati³

1. Graduate Student of 6th Term, Graduate College, Xinjiang Medical University,Urumqi 830000, China;2. Department of Geriatrics, Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University,Urumqi 830000, China;3. Institute of Pediatrics, Xinjiang Uygur Autonomous Region People's Hospital, Urumqi 830000, China;4. Department of General Cardiology, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China

Received:2012-03-25 Revised:1900-01-01 Online:2012-06-21 Published:2012-06-21

摘要/Abstract

摘要： 目的前瞻性观察缬沙坦与厄贝沙坦对糖尿病肾病患者微量尿白蛋白及血压的影响。方法前瞻性观察106例2型糖尿病肾病患者,按数字表法将患者随机分为A、B两组,均采用相应的基础降糖治疗后,A组(n=51)患者加用缬沙坦80 mg/d,B组患者(n=55)用厄贝沙坦150 mg/d,12周为1个疗程,每疗程观察微量白蛋白尿及血压,共3个疗程。结果 1缬沙坦及厄贝沙坦对微量尿白蛋白经3个疗程治疗后,差异有统计学意义(Z=-6.490,P<0.001)。两种药物对于微量尿白蛋白治疗在各疗程终点比较差异无统计学意义(P>0.05)。2缬沙坦及厄贝沙坦对血压经3个疗程治疗后差异有统计学意义(P<0.05)。两种药物对于收缩压治疗在各疗程终点比较,差异有统计学意义(P<0.05)。结论两组药物均有减少糖尿病肾病患者微量蛋白尿及降压作用,而厄贝沙坦比缬沙坦在降低血压方面更有优势。

关键词: 缬沙坦胶囊, 厄贝沙坦片, 糖尿病肾病, 尿微量白蛋白, 血压

Abstract: Objective This was a prospective observational study on effects of valsartan and irbesartan in patients with diabetic nephropathy on trace urinary albumin and blood pressure.Methods A prospective observational study was conducted on 106 cases of type 2 diabetic patients with nephropathy. The patients were randomly divided into two groups (A and B), patients in group A (n = 51) were treated with valsartan 80 mg/d, those in group B (n = 55) were treated with irbesartan 150 mg/d, for 12 weeks as a course, for each course of treatment, microalbuminuria, and blood pressure were measured for a total of three courses. Results (1) Valsartan and irbesartan groups' trace urinary albumin during three courses of treatment difference had statistically significant difference (Z=-6.490 P <0.001). (2) The blood pressure of the two groups during the three courses of treatment was significantly different (P <0.05); in each course of treatment the systolic blood pressure was significantly different (P<0.05).Conclusion Both drugs could reduce microalbuminuria and had antihypertensive effect in patients with diabetic nephropathy, while irbesartan was more effective in lowering blood pressure as compared with valsartan.

Key words: valsartan capsules, irbesartan tablets, diabetic nephropathy, urinary albumin, blood pressure

中图分类号:

R 587.2

阿布都沙拉木·阿布都;热衣木;刘涛;米尔班·阿不力克;木胡牙提. 缬沙坦胶囊、厄贝沙坦片治疗糖尿病肾病患者106例临床观察[J]. 首都医科大学学报, 2012, 33(3): 399-402.

Abudoushalamu·Abudoureyimu;LIU Tao;Mierban·Abulike;Muhuyati. Valsartan capsules, irbesartan tablets in the treatment of patients with diabetic nephropathy, clinical observation of 106 cases[J]. Journal of Capital Medical University, 2012, 33(3): 399-402.

[1]	左颖婷, 吴寿岭, 陈朔华, 田雪, 胥芹, 张怡君, 张晓丽, 王安心. 糖代谢异常人群中不同高血压亚型的心脑血管疾病风险[J]. 首都医科大学学报, 2023, 44(1): 42-48.
[2]	黄琪, 周亦伦, 孙雪峰. 共享外周循环对糖尿病肾病小鼠肾损伤的影响[J]. 首都医科大学学报, 2022, 43(5): 674-679.
[3]	于天宇, 姜世敏, 高红梅, 邹古明, 李文歌. 糖尿病肾病慢性肾脏病4期患者肾脏临床及病理因素与预后的关系[J]. 首都医科大学学报, 2022, 43(5): 707-712.
[4]	杨柳青, 田红梅, 石汉平. 三种饮食模式与慢性疾病研究进展[J]. 首都医科大学学报, 2022, 43(2): 311-320.
[5]	柳瑾, 齐新, 齐延芳, 冯娇娇, 彭金玲. 天津社区老年高血压患者心血管疾病危险因素分析[J]. 首都医科大学学报, 2021, 42(5): 804-809.
[6]	张爽, 马向科, 刘思维. 高血压脑出血合并肺部感染危险因素分析及防治[J]. 首都医科大学学报, 2021, 42(4): 660-663.
[7]	张冬雪, 林梅, 周璿, 刘文燕, 谷雅楠, 王左敏. 牙周状况对糖尿病肾病患者血糖控制的影响[J]. 首都医科大学学报, 2021, 42(2): 306-311.
[8]	谭静, 李静, 张迎花, 左雪冰. 冠状动脉早期粥样硬化症患者冠状动脉钙化的影响因素分析[J]. 首都医科大学学报, 2020, 41(6): 978-981.
[9]	卢晶, 杨卫利, 杨芳远, 曹曦, 杨金奎. 医学研究的凿光探秘者——杨金奎教授[J]. 首都医科大学学报, 2020, 41(5): 849-853.
[10]	李彬, 崔丽梅, 吕纳强, 严晔华, 郑晓敏, 陶静, 刘翠平. 初诊2型糖尿病患者糖尿病肾病与幽门螺旋杆菌感染的关系[J]. 首都医科大学学报, 2020, 41(1): 27-30.
[11]	诸国华, 孙希鹏, 唐桦, 华琦. 初发轻度高血压患者内皮功能与左心室肥厚的相关性研究[J]. 首都医科大学学报, 2019, 40(3): 369-373.
[12]	王蕤, 吴素萍, 徐品颖. 血浆miRNA-320C和miRNA-6088对Ⅱ型糖尿病肾病的诊断价值[J]. 首都医科大学学报, 2019, 40(3): 466-472.
[13]	边经纬, 尹晓辰, 李浩, 张苏丽, 王美丽, 刘慧荣. 血管紧张素Ⅱ1型受体自身抗体阳性雌鼠孕后出现妊娠期高血压样症状[J]. 首都医科大学学报, 2019, 40(2): 257-262.
[14]	赵明月, 刘博, 王鹏, 杨毅. 2型糖尿病患者肾脏病变与听力损失的相关性[J]. 首都医科大学学报, 2019, 40(1): 27-34.
[15]	周亚群, 丁存涛, 孙希鹏, 李静, 华琦. 原发性高血压患者红细胞分布宽度、中性粒细胞/淋巴细胞比值与内皮功能关系的研究[J]. 首都医科大学学报, 2018, 39(2): 292-298.

缬沙坦胶囊、厄贝沙坦片治疗糖尿病肾病患者106例临床观察

Valsartan capsules, irbesartan tablets in the treatment of patients with diabetic nephropathy, clinical observation of 106 cases

PDF

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价