首都医科大学学报 ›› 2012, Vol. 33 ›› Issue (3): 399-402.doi: 10.3969/j.issn.1006-7795.2012.03.024

• 临床研究 • 上一篇    下一篇

缬沙坦胶囊、厄贝沙坦片治疗糖尿病肾病患者106例临床观察

阿布都沙拉木·阿布都, 热衣木1,2, 刘涛2, 米尔班·阿不力克3, 木胡牙提4   

  1. 1. 新疆医科大学高校6期研究生班,乌鲁木齐 830000;2. 新疆医科大学附属中医院老年病科,乌鲁木齐 830000;3. 新疆维吾尔自治区人民医院儿科研究所,乌鲁木齐 830001;4. 新疆医科大学第一附属医院普通心内科, 乌鲁木齐 830054
  • 收稿日期:2012-03-25 修回日期:1900-01-01 出版日期:2012-06-21 发布日期:2012-06-21
  • 通讯作者: 木胡牙提

Valsartan capsules, irbesartan tablets in the treatment of patients with diabetic nephropathy, clinical observation of 106 cases

Abudoushalamu·Abudoureyimu, LIU Tao1,2, Mierban·Abulike2, Muhuyati3   

  1. 1. Graduate Student of 6th Term, Graduate College, Xinjiang Medical University,Urumqi 830000, China;2. Department of Geriatrics, Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University,Urumqi 830000, China;3. Institute of Pediatrics, Xinjiang Uygur Autonomous Region People's Hospital, Urumqi 830000, China;4. Department of General Cardiology, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China
  • Received:2012-03-25 Revised:1900-01-01 Online:2012-06-21 Published:2012-06-21

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404

被引次数

56

摘要： 目的 前瞻性观察缬沙坦与厄贝沙坦对糖尿病肾病患者微量尿白蛋白及血压的影响。方法 前瞻性观察106例2型糖尿病肾病患者,按数字表法将患者随机分为A、B两组,均采用相应的基础降糖治疗后,A组(n=51)患者加用缬沙坦80 mg/d,B组患者(n=55)用厄贝沙坦150 mg/d,12周为1个疗程,每疗程观察微量白蛋白尿及血压,共3个疗程。结果 1缬沙坦及厄贝沙坦对微量尿白蛋白经3个疗程治疗后,差异有统计学意义(Z=-6.490,P<0.001)。两种药物对于微量尿白蛋白治疗在各疗程终点比较差异无统计学意义(P>0.05)。2缬沙坦及厄贝沙坦对血压经3个疗程治疗后差异有统计学意义(P<0.05)。两种药物对于收缩压治疗在各疗程终点比较,差异有统计学意义(P<0.05)。结论 两组药物均有减少糖尿病肾病患者微量蛋白尿及降压作用,而厄贝沙坦比缬沙坦在降低血压方面更有优势。

关键词: 缬沙坦胶囊, 厄贝沙坦片, 糖尿病肾病, 尿微量白蛋白, 血压

Abstract: Objective This was a prospective observational study on effects of valsartan and irbesartan in patients with diabetic nephropathy on trace urinary albumin and blood pressure.Methods A prospective observational study was conducted on 106 cases of type 2 diabetic patients with nephropathy. The patients were randomly divided into two groups (A and B), patients in group A (n = 51) were treated with valsartan 80 mg/d, those in group B (n = 55) were treated with irbesartan 150 mg/d, for 12 weeks as a course, for each course of treatment, microalbuminuria, and blood pressure were measured for a total of three courses. Results (1) Valsartan and irbesartan groups' trace urinary albumin during three courses of treatment difference had statistically significant difference (Z=-6.490 P <0.001). (2) The blood pressure of the two groups during the three courses of treatment was significantly different (P <0.05); in each course of treatment the systolic blood pressure was significantly different (P<0.05).Conclusion Both drugs could reduce microalbuminuria and had antihypertensive effect in patients with diabetic nephropathy, while irbesartan was more effective in lowering blood pressure as compared with valsartan.

Key words: valsartan capsules, irbesartan tablets, diabetic nephropathy, urinary albumin, blood pressure

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