吡咯烷类二肽基肽酶-Ⅳ抑制剂的最新研究进展

doi:10.3969/j.issn.1006-7795.2012.04.025

首都医科大学学报 ›› 2012, Vol. 33 ›› Issue (4): 538-543.doi: 10.3969/j.issn.1006-7795.2012.04.025

吡咯烷类二肽基肽酶-Ⅳ抑制剂的最新研究进展

付文卓, 吴英婷, 张进禄

首都医科大学医学实验与测试中心, 北京 100069

收稿日期:2012-03-15 修回日期:1900-01-01 出版日期:2012-08-21 发布日期:2012-08-21
通讯作者: 张进禄

Recent advances in pyrrolidine derivatives as dipeptidyl peptidase-Ⅳ

FU Wen-zhuo, WU Ying-ting, ZHANG Jin-lu

Medical Experiment and Test Centre, Capital Medical University, Beijing 100069, China

Received:2012-03-15 Revised:1900-01-01 Online:2012-08-21 Published:2012-08-21

摘要/Abstract

摘要： 2型糖尿病是最常见的慢性病之一。含有吡咯烷类二肽基肽酶-Ⅳ抑制剂的药物对治疗2型糖尿病有一定的效果,所以近年对吡咯烷类二肽基肽酶-Ⅳ的抑制剂的研究备受关注。本文针对吡咯烷类二肽基肽酶-Ⅳ抑制剂的作用机制、结构特点、构效关系、开发现状及研究进展等进行综述,为通过基于结构的药物设计来获得新型的吡咯烷类二肽基肽酶(dipeptidyl peptidase-Ⅳ,DPP-4)抑制剂提供依据。

关键词: DPP-4抑制剂, 吡咯烷, 构效关系

Abstract: Type Ⅱ diabetes is one of the most common chronic diseases. The drugs which have pyrrolidine derivatives as dipeptidyl peptidase-Ⅳ have some effect in the treatment of type Ⅱ diabetes. Therefore intense interest has risen towards pyrrolidine derivatives as dipeptidyl peptidase-Ⅳ inhibitors recently. In this review, we summarized the mechanism, characteristic structure, structure-activity relationship and progress of pyrrolidine derivatives as dipeptidyl peptidase-Ⅳ, to provide a basis for structure-based drug design to the dipeptidyl peptidase-Ⅳ.

Key words: dipeptidyl peptidase-Ⅳ inhibitors, pyrrolidine derivatives, structure-activity relationship

中图分类号:

R587.1

付文卓;吴英婷;张进禄. 吡咯烷类二肽基肽酶-Ⅳ抑制剂的最新研究进展[J]. 首都医科大学学报, 2012, 33(4): 538-543.

FU Wen-zhuo;WU Ying-ting;ZHANG Jin-lu. Recent advances in pyrrolidine derivatives as dipeptidyl peptidase-Ⅳ[J]. Journal of Capital Medical University, 2012, 33(4): 538-543.

吡咯烷类二肽基肽酶-Ⅳ抑制剂的最新研究进展

Recent advances in pyrrolidine derivatives as dipeptidyl peptidase-Ⅳ

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