结肠癌中MMP-11和Moesin mRNA的表达与肿瘤转移及预后的关系

doi:10.3969/j.issn.1006-7795.2012.05.004

首都医科大学学报 ›› 2012, Vol. 33 ›› Issue (5): 575-580.doi: 10.3969/j.issn.1006-7795.2012.05.004

结肠癌中MMP-11和Moesin mRNA的表达与肿瘤转移及预后的关系

张丽萍¹, 蒲红伟², 陈晓¹, 李晓梅², 竞花兰³, 刘小山³

1. 新疆医科大学基础医学院生化教研室, 乌鲁木齐 830011;2. 新疆医科大学高职学院中心实验室, 乌鲁木齐 830011;3. 中山大学中山医学院法医学教研室,广州 510080

收稿日期:2012-06-18 修回日期:1900-01-01 出版日期:2012-10-21 发布日期:2012-10-21
通讯作者: 刘小山

Expression of mRNA of matrix metalloproteinase 11 and Moesin and its relevance to metastasis and prognosis in colorectal carcinoma

ZHANG Li-ping¹, PU Hong-wei², CHEN Xiao¹, LI Xiao-mei², JING Hua-lan³, LIU Xiao-shan³

1. Department of Biochemistry, Basic Medical College, Xinjiang Medical University, Urumqi 830011, China;2. Centre Lab, Vocational and Technical College,Xinjiang Medical University, Urumqi 830011, China;3. Department of Forensic Medicine, Zhongshan Medical College, Sun Yat-sen University, Guangzhou 510080, China

Received:2012-06-18 Revised:1900-01-01 Online:2012-10-21 Published:2012-10-21

摘要/Abstract

摘要： 目的检测结肠癌中基质金属蛋白酶-11(matrix metalloproteinase 11,MMP-11)和膜突蛋白(Moesin) mRNA表达水平并探讨其表达与肿瘤转移和预后的关系。方法采用原位杂交方法检测68例结肠癌组织及40例正常结肠组织中MMP-11和Moesin mRNA的表达情况。结果结肠癌组织中MMP-11和Moesin mRNA表达显著高于正常组织(P<0.05);癌组织中MMP-11和Moesin mRNA表达与组织学分化、淋巴结转移和临床分期有关,MMP-11表达还与浸润深度相关;MMP-11 mRNA阳性表达患者5年生存率(46.8%)明显低于阴性表达患者(75%),差异有统计学意义(P<0.05),但Moesin mRNA阳性表达患者五年生存率与阴性表达患者差异无统计学意义(P>0.05)。结论 MMP-11和Moesin mRNA高表达与结肠癌的浸润和转移密切相关,其中MMP-11可以作为结肠癌预后的指标。

关键词: 结肠癌, 基质金属蛋白酶-11, 膜突蛋白, 转移, 预后

Abstract: Objective To determine the expression of mRNA of matrix metalloproteinase 11 (MMP-11) and Moesin in colorectal carcinoma tissue, and to investigate the correlation between its expression and tumor metastasis and prognosis. Methods The expressions of mRNA of MMP-11 and Moesin in 68 tissues from patients with colorectal carcinoma and 40 tissues with normal colorectal mucosa were detected with in situ hybridization. Results The positive expression of mRNA of MMP-11 and Moesin in colorectal carcinoma tissue was 69.1%, and 60.3% respectively, which were both significantly higher than that in normal colorectal mucosa (P<0.05). The expression of mRNA of MMP-11 and Moesin was correlated with histologic differentiation, lymph node metastasis and clinical staging in patients with colorectal carcinoma. The expression of MMP-11 mRNA was also correlated with the depth of invasion of colorectal carcinoma into tissues (P<0.05). The 5-year survival rates were 46.8% and 75% in colorectal carcinoma patients with positive and negative expression of MMP-11 mRNA, respectively. The difference was statistically significant (P<0.05). There were no significant differences on the 5-year survival rates between the colorectal carcinoma patients with positive and negative expression of Moesin mRNA. Conclusion The expressions of mRNA of MMP-11 and Moesin are correlated with the progression and metastasis of colorectal carcinoma, and MMP-11 may be used as a predictor for prognosis of colorectal carcinoma.

Key words: colorectal carcinoma, matrix metalloproteinase 11, Moesin, metastasis, prognosis

中图分类号:

R 574.62

张丽萍;蒲红伟;陈晓;李晓梅;竞花兰;刘小山. 结肠癌中MMP-11和Moesin mRNA的表达与肿瘤转移及预后的关系[J]. 首都医科大学学报, 2012, 33(5): 575-580.

ZHANG Li-ping;PU Hong-wei;CHEN Xiao;LI Xiao-mei;JING Hua-lan;LIU Xiao-shan. Expression of mRNA of matrix metalloproteinase 11 and Moesin and its relevance to metastasis and prognosis in colorectal carcinoma[J]. Journal of Capital Medical University, 2012, 33(5): 575-580.

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结肠癌中MMP-11和Moesin mRNA的表达与肿瘤转移及预后的关系

Expression of mRNA of matrix metalloproteinase 11 and Moesin and its relevance to metastasis and prognosis in colorectal carcinoma

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