首都医科大学学报 ›› 2014, Vol. 35 ›› Issue (3): 320-323.doi: 10.3969/j.issn.1006-7795.2014.03.012

• 脑血管病的基础研究 • 上一篇    下一篇

小胶质细胞在酒精性脑损伤中的作用

李锦程, 赵海苹, 罗玉敏   

  1. 首都医科大学宣武医院脑血管病研究室, 北京 100053
  • 收稿日期:2014-02-17 出版日期:2014-06-21 发布日期:2014-06-14
  • 通讯作者: 罗玉敏,E-mail:yumin111@ccmu.edu.cn E-mail:yumin111@ccmu.edu.cn
  • 基金资助:

    国家自然科学基金项目(81271461,81201028)。

Effect of microglia in alcohol-induced brain damage

Li Jincheng, Zhao Haiping, Luo Yumin   

  1. Cerebrovascular Diseases Research Institute, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
  • Received:2014-02-17 Online:2014-06-21 Published:2014-06-14
  • Supported by:

    This study was supported by National Natural Science Foundation of China (81271461, 81201028).

摘要:

饮酒对中枢神经系统有重大影响,小胶质细胞是脑内原位免疫效应细胞,它在乙醇引起的神经毒性中有重要作用,可导致神经元死亡与退行性变;小胶质细胞有利于维持稳态而不是导致神经退行性变,小胶质细胞活化是乙醇引起损害的结果而不是损害的原因。本文对乙醇引起的神经元死亡和退行性变中小胶质细胞的反应及相应机制作一综述。

关键词: 酒精性脑损伤, 小胶质细胞, 炎性反应, 体内, 体外

Abstract:

Alcohol has a significant effect on the central nervous system, as the key immune effector cells in the brain, some studies proved that microglia plays an important role in the neurotoxicity of alcohol, which can lead to neuronal death and degeneration. Some investigations demonstrated that microglia is beneficial to maintain a steady state rather than causing nerve degeneration, microglia activation is the end of the damage induced by the alcohol rather than cause. This paper reviews the microglial response and related mechanism in neuronal death and degeneration caused by alcohol.

Key words: alcoholic brain damage, microglia, inflammation response, in vivo, in vitro

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