资癸女贞胶囊对子宫内膜薄性不育症妊娠结局影响的研究

doi:10.3969/j.issn.1006-7795.2014.04.007

首都医科大学学报 ›› 2014, Vol. 35 ›› Issue (4): 419-423.doi: 10.3969/j.issn.1006-7795.2014.04.007

• 更年期与妇科内分泌专题 • 上一篇下一篇

资癸女贞胶囊对子宫内膜薄性不育症妊娠结局影响的研究

王海文¹, 阮祥燕¹, Diethelm Wallwiener², Alfred O. Mueck^1,2

1. 首都医科大学附属北京妇产医院内分泌科, 北京 100026;
2. 德国图宾根大学妇产医院内分泌与绝经研究中心, 德国图宾根 D-72076

收稿日期:2014-06-10 出版日期:2014-08-21 发布日期:2014-07-22
通讯作者: 阮祥燕 E-mail:ruanxiangyan@163.com
基金资助:
北京市卫生系统高层次卫生技术人才培养计划项目（2009-3-52），首都医科大学附属北京妇产医院北京妇幼保健院学科带头人项目（2013-1）。

Effects of Zi Gui Nv Zhen capsule on pregnancy outcome in infertility due to thin endometrium

Wang Haiwen¹, Ruan Xiangyan¹, Diethelm Wallwiener², Alfred O. Mueck^1,2

1. Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China;
2. Department of Endocrinology, University Women's Hospital of Tubingen, Tuebingen D-72076, Germany

Received:2014-06-10 Online:2014-08-21 Published:2014-07-22
Supported by:
This study was supported by Beijing Municipality Health Technology High-level Talent(2009-3-52), Project of Discipline Leader, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital(2013-1).

摘要/Abstract

摘要：

目的观察资癸女贞胶囊对子宫内膜薄性不育症妊娠结局的影响。方法观察165例子宫内膜过薄导致不育症的患者，采用随机数字表法分为观察组80例和对照组85例。对照组单纯应用雌二醇治疗，在对照组治疗的基础上观察组加服资癸女贞胶囊，监测排卵后子宫内膜螺旋动脉血流搏动指数及阻力指数，子宫内膜厚度，黄体期血清孕酮及雌二醇质量浓度，追访妊娠及活产情况。结果观察组较对照组子宫内膜厚度明显增加，A型内膜数量增加（P<0.05）；观察组排卵日子宫动脉血流搏动指数及阻力指数均明显低于对照组（P<0.05）；治疗3个周期后，观察组妊娠率明显高于对照组（P<0.05）；随访观察组妊娠率明显高于对照组（P<0.05）；活产率两组差异没有统计学意义（P>0.05）。结论应用资癸女贞胶囊联合雌二醇治疗子宫内膜薄性不育症，资癸女贞胶囊可通过降低子宫动脉血流阻力增加子宫动脉的血流量，通过增加雌激素受体表达，使雌激素能更好的发挥作用，进而改善子宫内膜厚度及类型，提高子宫内膜容受性，中药复方制剂通过调节全身神经内分泌系统，改善卵巢功能，提高卵子质量，从而提高临床妊娠率。

关键词: 资癸女贞胶囊, 子宫内膜, 不育不孕症, 妊娠

Abstract:

Objective To observe the effects of Zi Gui Nv Zhen capsule on pregnancy outcome in infertility due to thin endometrium. Methods To observe one hundred sixty-five infertility patients with thin endometrium. These patients were divided into two groups by random number table method. The observation group had 80 cases, control group 85 cases. The control group was treated with estradiol valerate alone. Besides the treatment given to the control group, patients of observation group were given Zi Gui Nv Zhen capsule for treatment. Endometrial spiral artery blood flow pulsation index(PI) and endometrial spiral artery blood flow resistance index(RI), endometrium thickness, luteal phase serum progesterone and estradiol of after ovulation were observed and the patients were followed up for pregnancy and live birth rates. Results The thickenness of observation group type A endometrium of patients increased significantly(P<0.05) as compared with the control group. Uterus artery RI and PI in ovulation day of patients in the observation group was significantly lower than that of control group(P<0.05). After three cycles the observation group had significantly higher pregnancy rate, follow-up found that the pregnancy rate in the observation group was significantly higher than that of the control group(P<0.05); live birth rate in two groups had no significant statistical difference. Conclusion Application of Zi Gui Nv Zhen capsule combined with estradiol valerate therapy in thin endometrium of infertile patients could reduce uterine artery resistance, increase uterine artery blood flow, increase the expression of estrogen receptor, so estrogen can better play its role, thereby improved endometrial thickness and type, to improve endometrial receptivity traditional Chinese medicine might regulate systemic neuroendocrine system, improve ovarian function, improve ovum quality, thereby improve clinical pregnancy rate.

Key words: Zi Gui Nv Zhen capsule, endometrium, infertility, pregnancy

中图分类号:

R271.14

王海文, 阮祥燕, Diethelm Wallwiener, Alfred O. Mueck. 资癸女贞胶囊对子宫内膜薄性不育症妊娠结局影响的研究[J]. 首都医科大学学报, 2014, 35(4): 419-423.

Wang Haiwen, Ruan Xiangyan, Diethelm Wallwiener, Alfred O. Mueck. Effects of Zi Gui Nv Zhen capsule on pregnancy outcome in infertility due to thin endometrium[J]. Journal of Capital Medical University, 2014, 35(4): 419-423.

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资癸女贞胶囊对子宫内膜薄性不育症妊娠结局影响的研究

Effects of Zi Gui Nv Zhen capsule on pregnancy outcome in infertility due to thin endometrium

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