多囊卵巢综合征患者促甲状腺激素浓度与血脂关系的研究

doi:10.3969/j.issn.1006-7795.2014.04.008

首都医科大学学报 ›› 2014, Vol. 35 ›› Issue (4): 424-427.doi: 10.3969/j.issn.1006-7795.2014.04.008

• 更年期与妇科内分泌专题 • 上一篇下一篇

多囊卵巢综合征患者促甲状腺激素浓度与血脂关系的研究

殷冬梅¹, 阮祥燕¹, 卢永军¹, 武红琴¹, 田玄玄¹, Diethelm Wallwiener², Alfred O. Mueck^1,2

1. 首都医科大学附属北京妇产医院内分泌科, 北京 100026;
2. 德国图宾根大学妇产医院内分泌与绝经中心, 德国图宾根 D-72076

收稿日期:2014-06-10 出版日期:2014-08-21 发布日期:2014-07-22
通讯作者: 阮祥燕 E-mail:ruanxiangyan@163.com
基金资助:
国家外专局引智项目（GDJ20141100017）;北京市卫生系统高层次卫生技术人才培养计划项目（2009-3-52）;首都医科大学附属北京妇产医院、北京妇幼保健院学科带头人项目（2013-1）。

Association between thyroid-stimulating hormone and serum lipid in patients with polycystic ovary syndrome

Yin Dongmei¹, Ruan Xiangyan¹, Lu Yongjun¹, Wu Hongqin¹, Tian Xuanxuan¹, Diethelm Wallwiener², Alfred O. Mueck^1,2

1. Department of Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China;
2. Department of Endocrinology, University Women's Hospital of Tubingen, Tubingen D-72076, Germany

Received:2014-06-10 Online:2014-08-21 Published:2014-07-22
Supported by:
This study was supported by China Administration of Foreign Experts Affairs Yinzhi Project(GDJ20141100017); Beijing Municipality Health Technology High-level Talent(No 2009-3-52); Project of Discipline Leader, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital(2013-1).

摘要/Abstract

摘要：

目的研究不同浓度血清促甲状腺激素（thyroid-stimulating hormone，TSH）的多囊卵巢综合征（polycystic ovary syndrome，PCOS）患者临床特征及内分泌代谢指标之间的差异。方法选择110例多囊卵巢综合征患者，测量身高、体质量、腰围、臀围；应用化学发光法分析测定血清TSH、总胆固醇（total cholesterol，TC）、低密度脂蛋白胆固醇（low-density lipoprotein cholesterol，LDL-C）、高密度脂蛋白胆固醇（high-density lipoprotein cholesterol，HDL-C）、三酰甘油（triglycerides，TG）、空腹血糖（fasting blood glucose，FBG）、空腹胰岛素（fasting serum insulin，INS）、卵泡刺激素（follicle stimulating hormone，FSH）、黄体生成素（luteinizing hormone，LH）、睾酮（testosterone，T）、催乳素（prolactin，PRL）、雌二醇（estrogen，E2）；计算体质量指数（body mass index，BMI）、腰臀比（waist hip ratio，WHR）、黄体生成素与卵泡刺激素的比值（LH-to-FSH ratio，LH/FSH）；采用稳态模型评估的胰岛素抵抗指数（homeostasis model assessment insulin resistance，HOMA-IR），按血清TSH浓度将其分为2组：A组71例，TSH<2.5 mIu/L；B组39例TSH≥2.5 mIu/L；比较2组上述各项指标的差异及TSH与各项指标间的相关性。结果 B组（TSH≥2.5 mIu/L）PCOS患者的WHR及LDL高于A组（TSH<2.5 mIu/L），差异有统计学意义（P<0.05）。TSH浓度的升高与腰臀比、血清总胆固醇、低密度脂蛋白胆固醇、PRL浓度呈正相关。2组间其他临床、代谢指标相比无统计学意义（P>0.05）。结论 TSH与脂代谢指标有相关性，TSH≥2.5 mIu/L的PCOS患者，脂代谢发生了显著的变化。

关键词: 多囊卵巢综合征, 促甲状腺激素, 脂代谢

Abstract:

Objective To investigate the differences in clinical features, endocrine metabolic parameters of polycystic ovary syndrome patients with different levels of serum thyroid-stimulating hormone. Methods One hundred and ten PCOS patients were enrolled. Height, weight, waist circumference, hip circumferences were measured. Chemiluminescence was applied for measuring thyroid-stimulating hormone(TSH), total cholesterol(TC), low density lipoprotein(LDL), high density lipoprotein(HDL), triglyceride(TG), fasting blood-glucose(FBG), fasting insulin(INS), follicle-stimulating hormone(FSH), luteinizing hormone(LH), testosterone(T), prolactin(PRL) and estradiol(E2); Body mass index(BMI), waist-to-hip circumference ratio(WHR), LH-to-FSH ratio(LH/FSH) were calculated; The insulin resistance index evaluated by steady-state model(HOMA-IR); all patients were divided into two groups according to serum thyroid-stimulating hormone: group A had 71 cases with TSH<2.5 mIu/L, as group B of 39 cases with TSH≥2.5 mIu/L; all the hormone parameters mentioned above were compared between group A and B, and the correlation with TSH. Results The WHR and LDL in group B(TSH≥2.5 mIu/L) is significantly higher than that of the patients in group A(TSH<2.5 mIu/L). The increase of TSH concentration positively correlates to an increase of WHR, TC, LDL-C and PRL. No significant differences are shown in other clinical and metabolic indicators. Conclusion There was a significant correlation between TSH and lipid metabolic parameters. Women with polycystic ovary syndrome and with thyroid-stimulating hormone≥2.5 mIu/L had significantly endocrine and metabolic changes.

Key words: polycystic ovary syndrome, thyroid-stimulating hormone, lipid metabolism

中图分类号:

R711.75

殷冬梅, 阮祥燕, 卢永军, 武红琴, 田玄玄, Diethelm Wallwiener, Alfred O. Mueck. 多囊卵巢综合征患者促甲状腺激素浓度与血脂关系的研究[J]. 首都医科大学学报, 2014, 35(4): 424-427.

Yin Dongmei, Ruan Xiangyan, Lu Yongjun, Wu Hongqin, Tian Xuanxuan, Diethelm Wallwiener, Alfred O. Mueck. Association between thyroid-stimulating hormone and serum lipid in patients with polycystic ovary syndrome[J]. Journal of Capital Medical University, 2014, 35(4): 424-427.

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多囊卵巢综合征患者促甲状腺激素浓度与血脂关系的研究

Association between thyroid-stimulating hormone and serum lipid in patients with polycystic ovary syndrome

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