阿尔茨海默病的静息态功能磁共振、弥散张量成像及脑灌注研究进展

doi:10.3969/j.issn.1006-7795.2015.04.025

首都医科大学学报 ›› 2015, Vol. 36 ›› Issue (4): 640-644.doi: 10.3969/j.issn.1006-7795.2015.04.025

阿尔茨海默病的静息态功能磁共振、弥散张量成像及脑灌注研究进展

王志群¹, 李坤成^2,3,4

1. 北京中医药大学东方医院放射科, 北京 100078;
2. 首都医科大学宣武医院放射科, 北京 100053;
3. 教育部神经变性病重点实验室首都医科大学, 北京 100053;
4. 北京市磁共振成像脑信息学重点实验室, 北京 100053

收稿日期:2014-01-13 出版日期:2015-08-21 发布日期:2015-07-17
通讯作者: 李坤成 E-mail:likuncheng1955@aliyun.com
基金资助:
国家自然科学基金(81471649,81370037),北京市自然科学基金(7153166)。

Resting state functional MRI, DTI and PWI in the Alzheimer's disease

Wang Zhiqun¹, Li Kuncheng^2,3,4

1. Department of Radiology, Dongfang Hospital of Beijing University of Chinese Medicine, Beijing 100078, China;
2. Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China;
3. Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Capital Medical University, Beijing 100053, China;
4. Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing 100053, China

Received:2014-01-13 Online:2015-08-21 Published:2015-07-17
Supported by:
This study was supported by National Natural Science Foundation of China(81471649, 81370037), Natural Science Foundation of Beijing(7153166).

摘要/Abstract

摘要：

阿尔茨海默病(Alzheimer's disease,AD)以认知和记忆能力下降为主要特征,轻度认知功能障碍是AD的早期阶段,AD的病理生理机制目前尚不清楚,本文综述了AD有关的神经影像学研究,通过应用磁共振成像新技术包括静息态脑功能成像、弥散张量成像、脑灌注成像,有助于我们从功能、结构和灌注的角度更深入理解AD的病理生理机制。本文对此做简要综述。

关键词: 阿尔茨海默病, 轻度认知功能障碍, 功能磁共振, 弥散张量成像, 脑灌注成像

Abstract:

Alzheimer's disease(AD) is characterized as cognitive and memory decline. Mild cognitive impairment(MCI) is the early stage of AD. The pathophysiology of AD is not very clear. In the present article, we reviewed the previous neuroimaging study of AD. By using the new MRI techniques including resting state functional MRI(fMRI), diffusion tensor imaging(DTI) and perfusion weighted imaging(PWI), we can acquire deep understanding of the pathophysiology of AD from the prospect of function, structure and perfusion.

Key words: Alzheimer's disease, mild cognitive impairment, functional MRI, diffusion tensor imaging, perfusion weighted imaging

中图分类号:

R741

王志群, 李坤成. 阿尔茨海默病的静息态功能磁共振、弥散张量成像及脑灌注研究进展[J]. 首都医科大学学报, 2015, 36(4): 640-644.

Wang Zhiqun, Li Kuncheng. Resting state functional MRI, DTI and PWI in the Alzheimer's disease[J]. Journal of Capital Medical University, 2015, 36(4): 640-644.

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阿尔茨海默病的静息态功能磁共振、弥散张量成像及脑灌注研究进展

Resting state functional MRI, DTI and PWI in the Alzheimer's disease

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