北京市昌平区自然人群黄斑病变情况调查及分析

doi:10.3969/j.issn.1006-7795.2015.06.004

首都医科大学学报 ›› 2015, Vol. 36 ›› Issue (6): 853-856.doi: 10.3969/j.issn.1006-7795.2015.06.004

• 糖尿病基础与临床研究 • 上一篇下一篇

北京市昌平区自然人群黄斑病变情况调查及分析

曹曦^1,2, 袁明霞^1,2, 信中^1,2, 谢荣荣^1,2, 杨金奎^1,2

1. 首都医科大学附属北京同仁医院内分泌科, 北京 100730;
2. 糖尿病防治研究北京市重点实验室, 北京 100730

收稿日期:2015-10-21 出版日期:2015-12-21 发布日期:2015-12-18
通讯作者: 杨金奎 E-mail:jinkui.yang@gmail.com
基金资助:
北京市重大科技计划项目(D12110000412001);临床流行病学北京市重点实验室2015开放课题(2015LCLB02)。

Investigation and analysis of macular diseases in natural population and diabetes patients in Changping District, Beijing

Cao Xi^1,2, Yuan Mingxia^1,2, Xin Zhong^1,2, Xie Rongrong^1,2, Yang Jinkui^1,2

1. Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China;
2. Beijing Key Laboratory of Diabetes Research and Care, Beijing 100730, China

Received:2015-10-21 Online:2015-12-21 Published:2015-12-18
Supported by:
This study was supported by Beijing Major Science and Technology Projects(D12110000412001), 2015 Open Topics of Beijing Key Laboratory of Clinical Epidemiology(2015LCLB02).

摘要/Abstract

摘要： 目的利用光学相干断层扫描仪(optical coherence tomography,OCT)筛查北京市昌平区自然人群黄斑病变情况,并分析黄斑病变类型,以及影响黄斑病变的危险因素。方法根据2011年"北京市昌平区卫生与人群健康状况调查",最终521例受试者完成体格检查和血液生化指标的测定,包括空腹血糖、口服葡萄糖耐量试验(oral glucose tolerance test,OGTT-2 h)测血糖和糖化血红蛋白,以及OCT检查黄斑。结果 521例受试者经过筛查分为2组,其中黄斑正常组503例,黄斑病变组18例,分为5种类型:老年型黄斑(2例),弥漫性黄斑水肿无囊肿(5例),黄斑囊样水肿(6例),牵引性黄斑水肿(3例),浆液性视网膜脱离(2例)。空腹血糖(fasting plasma glucose,FPG)(P=0.024),餐后2 h血糖(OGTT-2 h PG)(P=0.029),血清总胆固醇(total cholesterol,TC)(P=0.024)和低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)(P=0.044)是黄斑患病的独立危险因素。黄斑患者的黄斑中心凹厚度显著大于正常对照组(P < 0.001)。结论空腹血糖、餐后2 h血糖、血清总胆固醇和低密度脂蛋白是黄斑病变的独立危险因素;黄斑病变患者的黄斑显著增厚。

关键词: 空腹血糖, 黄斑病变, 光学相干断层扫描

Abstract: Objective To investigate the macular disorders by optical coherence tomography(OCT) in patients and residents of Changping District, Beijing, and to analyze the type and risk factors of macular diseases. Methods In a cross-sectional population-based study, OCT was performed for subjects from the 2011 Health Examination Survey in Beijing. The subjects also received physical examination and laboratory measurements including fasting plasma glucose(FPG), oral glucose tolerance test(OGTT)-2 h plasma glucose(2 h PG), hemoglobin A1C(HbA1c), uric acid and lipid profiles, in addition to completing a general health questionnaire. Results The study included 521 subjects who had at least one eye meeting study eligibility criteria. Of all subjects, two patients had age-related macular degeneration(AMD), five patients had diffuse macular edema without cysts, six patients had cystoid macular edema, three patients had tractional macular edema, two patients had serious retinal detachments. More importantly, FPG(P=0.024), OGTT-2 h PG(P=0.029), total cholesterol(P=0.024) and low-density lipoprotein(LDL)(P=0.044) cholesterol were found to be the independent risk factors for macular disease. Central subfield thickness(CST) of the retina was significantly greater in patients with macular disease than in normal controls(P < 0.001). Conclusion Patients with macular disease had greater central subfield thickness. FPG, 2 h PG, total cholesterol and LDL-C were found to be the independent risk factors for macular disease.

Key words: fasting plasma glucose, macular disease, optical coherence tomography

中图分类号:

R589

曹曦, 袁明霞, 信中, 谢荣荣, 杨金奎. 北京市昌平区自然人群黄斑病变情况调查及分析[J]. 首都医科大学学报, 2015, 36(6): 853-856.

Cao Xi, Yuan Mingxia, Xin Zhong, Xie Rongrong, Yang Jinkui. Investigation and analysis of macular diseases in natural population and diabetes patients in Changping District, Beijing[J]. Journal of Capital Medical University, 2015, 36(6): 853-856.

参考文献

[1] Lang G E. Diabetic macular edema[J]. Ophthalmologica, 2012,227(Suppl 1):21-29.
[2] Fong D S, Ferris F L 3rd, Davis M D, et al. Causes of severe visual loss in the early treatment diabetic retinopathy study: ETDRS report no. 24. Early Treatment Diabetic Retinopathy Study Research Group[J]. Am J Ophthalmol, 1999,127(2):137-141.
[3] Brown J C, Solomon S D, Bressler S B, et al. Detection of diabetic foveal edema: contact lens biomicroscopy compared with optical coherence tomography[J]. Arch Ophthalmol, 2004,122(3):330-335.
[4] Minassian D C, Owens D R, Reidy A. Prevalence of diabetic macular oedema and related health and social care resource use in England[J]. Br J Ophthalmol, 2012,96(3):345-349.
[5] Browning D J, McOwen M D, Bowen R M Jr, et al. Comparison of the clinical diagnosis of diabetic macular edema with diagnosis by optical coherence tomography[J]. Ophthalmol, 2004,111(4):712-715.
[6] Wong T Y, Klein R, Sun C, et al. Age-related macular degeneration and risk for stroke[J]. Ann Intern Med, 2006,145(2):98-106.
[7] Yang W, Lu J, Weng J, et al. Prevalence of diabetes among men and women in China[J]. N Engl J Med, 2010,362(12):1090-1101.
[8] Lopes de Faria J M, Jalkh A E, Trempe C L, et al. Diabetic macular edema: risk factors and concomitants[J]. Acta Ophthalmol Scand, 1999,77(2):170-175.
[9] Massin P, Erginay A, Haouchine B, et al. Retinal thickness in healthy and diabetic subjects measured using optical coherence tomography mapping software[J]. Eur J Ophthalmol, 2002,12(2):102-108.
[10] Bressler N M, Edwards A R, Antoszyk A N, et al. Retinal thickness on stratus optical coherence tomography in people with diabetes and minimal or no diabetic retinopathy[J]. Am J Ophthalmol, 2008,145(5):894-901.
[11] Pires I, Bernardes R C, Lobo C L, et al. Retinal thickness in eyes with mild nonproliferative retinopathy in patients with type 2 diabetes mellitus: comparison of measurements obtained by retinal thickness analysis and optical coherence tomography[J]. Arch Ophthalmol, 2002,120(10):1301-1306.
[12] Zander E, Herfurth S, Bohl B, et al. Maculopathy in patients with diabetes mellitus type 1 and type 2: associations with risk factors[J]. Br J Ophthalmol, 2000,84(8):871-876.
[13] Peyman M, Tajunisah I, Loo A, et al. Scanning laser edema index: a reliable tool to correlate with diabetic retinopathy and systemic risk factors?[J]. J Diabetes Complications, 2012,26(3):210-213.
[14] Sasaki M, Kawashima M, Kawasaki R, et al. Association of serum lipids with macular thickness and volume in type 2 diabetes without diabetic macular edema[J]. Invest Ophthalmol Vis Sci, 2014,55(3):1749-1753.
[15] Guan K, Hudson C, Wong T, et al. Retinal hemodynamics in early diabetic macular edema[J]. Diabetes, 2006,55(3):813-818.
[16] 高辉,刘怀栋,李焕丽.中医玄府辨证治疗非增殖期糖尿病视网膜病变32例临床观察[J].中国煤炭工业医学杂志,2014,17(4):641-644.
[17] 袁明霞,信中,冯建萍,等.北京市昌平区自然人群糖尿病视网膜病变患病率调查及危险因素分析[J].首都医科大学学报,2012,33(5):669-675.
[18] 信中,袁明霞,冯建萍,等.空腹血糖、OGTT 2 h血糖和糖化血红蛋白同糖尿病视网膜病变的相关性比较[J].首都医科大学学报,2012,33(4):62-65.

北京市昌平区自然人群黄斑病变情况调查及分析

Investigation and analysis of macular diseases in natural population and diabetes patients in Changping District, Beijing

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