高危组前列腺癌根治术后雄激素剥夺治疗联合早期放射治疗对局部控制及近期生存率的影响

doi:10.3969/j.issn.1006-7795.2016.03.012

首都医科大学学报 ›› 2016, Vol. 37 ›› Issue (3): 318-322.doi: 10.3969/j.issn.1006-7795.2016.03.012

• 前列腺癌发病机制与临床治疗研究 • 上一篇下一篇

高危组前列腺癌根治术后雄激素剥夺治疗联合早期放射治疗对局部控制及近期生存率的影响

靳松¹, 张天², 郑颖洁², 宋黎明¹, 平浩¹, 瓦斯里江·瓦哈甫¹, 牛亦农¹, 邢念增¹

1. 首都医科大学附属北京朝阳医院泌尿外科, 北京 100020;
2. 首都医科大学附属北京朝阳医院放疗科, 北京 100020

收稿日期:2016-04-06 出版日期:2016-06-21 发布日期:2016-06-13
通讯作者: 牛亦农, 邢念增 E-mail:farmerniu@163.com;nianzeng2006@vip.sina.com
基金资助:
北京市卫生系统高层次卫生技术人才(2011-3-014)。

Effect of early radiotherapy combined with androgen deprivation therapy after radical prostatectomy on local control and survival in patients with high-risk prostate cancer

Jin Song¹, Zhang Tian², Zheng Yingjie², Song Liming¹, Ping Hao¹, Wasilijiang·wahafu¹, Niu Yinong¹, Xing Nianzeng¹

1. Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China;
2. Department of Radiotherapy, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China

Received:2016-04-06 Online:2016-06-21 Published:2016-06-13
Supported by:
This study was supported by the High-level Technical Personnel of Beijing Health System (2011-3-014).

摘要/Abstract

摘要： 目的探讨内分泌治疗合并早期放射治疗对高危前列腺癌患者根治术后的局部控制及近期生存率的影响。方法收集首都医科大学附属北京朝阳医院14例高危组前列腺癌根治术后行三维适形放射治疗(three dimension-conformal radiotherapy, 3D-CRT)或调强放射治疗(intensive modulation radiotherapy, IMRT)联合内分泌治疗的患者,收集患者基本信息、手术信息,并随访放射治疗期间的相关合并症、术后及放射治疗后前列腺特异性抗原(prostate specific antigen,PSA)变化与生存状态,并进行统计学分析。结果 14例患者治疗后随访时间2~52个月,平均随访时间20个月。在放射治疗疗期间,5例患者出现轻度尿频、尿急,2例出现轻度腹泻、腹胀,1例患者出现白细胞一过性降低,血红蛋白、血小板无异常,无其他合并症发生;1例患者放射治疗疗后24个月,PSA由最低0.056 ng/mL升高至6 ng/mL,但无明显局部复发和远处转移迹象,恢复比卡鲁胺及亮丙瑞林治疗5个月后,PSA降至1.539 ng/mL。其他13例患者无生化指标反弹及临床局部复发。结论高危前列腺癌根治术后,早期辅助放射治疗联合内分泌治疗可以改善患者局部控制及近期生存率。

关键词: 高危前列腺癌, 前列腺癌根治术, 放射治疗, 雄激素剥夺治疗

Abstract: Objective To investigate the effect of radiotherapy combined with androgen deprivation therapy after radical prostatectomy on local control and survival in patients with high-risk prostate cancer.Methods Fourteen patients with high-risk prostate cancer seen from 2010 to 2015 were treated with three dimension-conformal radiotherapy (3D-CRT) or intensive modulation radiotherapy (IMRT) combined with androgen deprivation therapy after radical prostatectomy. The basic information, surgery, radiotherapy complications, prostate specific antigen (PSA) after surgery and survival condition of the patients were collected.Results Mean follow-up period was 20 (2-52) months. During radiotherapy, no severe complications occurred in the fourteen treated patients, 5 patients had mild frequent or urgent urination, 2 patients had mild diarrhea and abdominal distension, and only 1 patient had transient reduced leucocyte count without abnormal hemoglobin and platelet. PSA increased to 6 ng/mL from 0.056 ng/mL after radiotherapy without local recurrence and metastasis in one patient who resumed taking androgen deprivation therapy (bicalutamide and leuprorelin) for 5 months and PSA decreased to 1.539 ng/mL. The other 13 patients survived without biochemical and local recurrence.Conclusion Early adjuvant radiotherapy combined with androgen deprivation therapy after radical prostatectomy improve the local control and survival in the patients of high-risk prostate cancer.

Key words: high-risk prostatic cancer, radical prostatectomy, radiotherapy, androgen deprivation therapy

中图分类号:

R737.25

靳松, 张天, 郑颖洁, 宋黎明, 平浩, 瓦斯里江·瓦哈甫, 牛亦农, 邢念增. 高危组前列腺癌根治术后雄激素剥夺治疗联合早期放射治疗对局部控制及近期生存率的影响[J]. 首都医科大学学报, 2016, 37(3): 318-322.

Jin Song, Zhang Tian, Zheng Yingjie, Song Liming, Ping Hao, Wasilijiang·wahafu, Niu Yinong, Xing Nianzeng. Effect of early radiotherapy combined with androgen deprivation therapy after radical prostatectomy on local control and survival in patients with high-risk prostate cancer[J]. Journal of Capital Medical University, 2016, 37(3): 318-322.

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高危组前列腺癌根治术后雄激素剥夺治疗联合早期放射治疗对局部控制及近期生存率的影响

Effect of early radiotherapy combined with androgen deprivation therapy after radical prostatectomy on local control and survival in patients with high-risk prostate cancer

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