关键词: 血栓前状态, 下肢深静脉血栓形成, 妊娠

Abstract: Objective To investigate the changes of blood coagulation indexes before and after cesarean section in pregnant women with prethrombotic state.Methods Totally 66 cases with prethrombotic state in the diagnosis of "snowstorm sign" by ultrasound were enrolled, compared with the same period hospitalized pregnant women in 66 cases of normal lower limb venous ultrasound. The prothrombin time (PT) and activated partial thromboplastin time (APTT), thrombin time (TT), fibrin original (FBG) and D dimer (D-D) in the two groups were compared to the corresponding analysis, to study the correlation between coagulation related parameters change and prethrombotic state.Results There was no significant difference between the prethrombotic state group and normal pregnancy group in PT, TT, FBG (P >0.05). APTT and D-D in the prethrombotic state was (30.79±3.89)s and (480.81±189.75)ng/mL,which have significant difference compared to (32.44±3.59)s and (364.74±81.76)ng/mL in the normal pregnancy group (P <0.05). Conclusion The determination of D-D is helpful for the diagnosis of gestational prethrombotic state.It is necessary to further diagnosis by lower limb venous ultrasound for the obviously increased cases. The prethrombotic state in pregnant women should be monitored for D dimer and ultrasound to disover whether the deep venous thrombosis of lower extremity was formed, and avoid severe and fatal pulmonary embolism.

Key words: prethrombotic state, deep venous thrombosis, pregnancy