血红蛋白与成人代谢综合征及其组分关联性的五年队列研究

doi:10.3969/j.issn.1006-7795.2016.04.019

首都医科大学学报 ›› 2016, Vol. 37 ›› Issue (4): 509-512.doi: 10.3969/j.issn.1006-7795.2016.04.019

血红蛋白与成人代谢综合征及其组分关联性的五年队列研究

刘相佟^1,2, 陶丽新^1,2, 杨昆^1,2, 李海彬^1,2, 郭晋^1,2, 郭秀花^1,2

1. 首都医科大学公共卫生学院流行病与卫生统计学系, 北京 100069;
2. 临床流行病学北京市重点实验室, 北京 100069

收稿日期:2015-12-08 出版日期:2016-08-21 发布日期:2016-07-18
通讯作者: 郭秀花 E-mail:statguo@ccmu.edu.cn
基金资助:
国家自然科学基金（81530087，81373099），北京市自然科学基金（7131002）。

Association between hemoglobin and metabolic syndrome: a five-year follow-up

Liu Xiangtong^1,2, Tao Lixin^1,2, Yang Kun^1,2, Li Haibin^1,2, Guo Jin^1,2, Guo Xiuhua^1,2

1. Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing 100069, China;
2. Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing 100069, China

Received:2015-12-08 Online:2016-08-21 Published:2016-07-18
Supported by:
This study was supported by National Natural Science Foundation of China(81530087,81373099),Natural Science Foundation of Beijing(7131002).

摘要/Abstract

摘要： 目的探讨血红蛋白与代谢综合征（metabolic syndrome，MetS）及其组分（肥胖、血压、血糖、血脂）的关联性。方法选取来自北京电力医院和北京小汤山医院的体检者为研究对象，采用多因素Logistic回归分析MetS发病风险随基线血红蛋白（hemoglobin，Hb）浓度的变化。结果 MetS 5年发病率为14.52%，MetS组基线Hb[（144.46±13.47）g/L]明显高于未患MetS组[（141.00±14.70）g/L]，差异有统计学意义（t=-5.49，P<0.001）。多因素Logistic回归分析显示，在调整了年龄、性别后，Hb的升高与MetS发病风险的增加呈正相关。以最低四分位数作参照，随Hb升高，比值比（odds ratio，OR）值分别为1.238（95%CI：0.963～1.591）、1.243（95%CI：0.965～1.602）、1.439（95%CI：1.113～1.859）。结论 Hb与MetS及其组分存在相关性，可作为MetS发病的一个预测指标。

关键词: 血红蛋白, 代谢综合征, 肥胖, 血压, 血脂

Abstract: Objective To explore the association between hemoglobin(Hb) and metabolic syndrome (MetS). Methods A total of 3773 individuals in Beijing Tongren Hospital, Dianli Hospital and Xiaotangshan Hospital from 2007 to 2012 were recruited in the study. The subjects were divided into four quartiles according to Hb. Multivariate logistic regression was applied for data analysis. Results There were 2 509 males (average 47.94±15.41 years old) and 1 264 females (average 46.63±12.90 years old). Five-year accumulated incidence of MetS was 14.52%. The average baseline Hb was significantly higher in the subjects with MetS[(144.46±13.47) g/L] than those without MetS[(141.00±14.70) g/L] (t=-5.49, P<0.001). Multivariate Logistic regression analysis revealed that after adjustment of age and sex, elevated baseline Hb was positively correlated to the higher risk of MetS. Compared with individuals with lowest Hb, subjects with highest Hb were more vulnerable to MetS (OR=1.439, 95%CI:1.113-1.859). Conclusion Hb is closely correlated with MetS and its components, and it can be used as a predictor of MetS.

Key words: hemoglobin, metabolic syndrome, obesity, blood pressure, lipids

中图分类号:

R446
R589

刘相佟, 陶丽新, 杨昆, 李海彬, 郭晋, 郭秀花. 血红蛋白与成人代谢综合征及其组分关联性的五年队列研究[J]. 首都医科大学学报, 2016, 37(4): 509-512.

Liu Xiangtong, Tao Lixin, Yang Kun, Li Haibin, Guo Jin, Guo Xiuhua. Association between hemoglobin and metabolic syndrome: a five-year follow-up[J]. Journal of Capital Medical University, 2016, 37(4): 509-512.

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血红蛋白与成人代谢综合征及其组分关联性的五年队列研究

Association between hemoglobin and metabolic syndrome: a five-year follow-up

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