关键词: 食管静脉曲张, 聚桂醇, 内镜下硬化治疗, 血管内联合血管旁

Abstract: Objective To investigate the efficacy of Endoscopic intravariceal plus paravariceal injection lauromacrogol sclerotherapy for treatment of esophageal variceal and the methods to improve the efficacy. Methods We retrospectively analyzed the 260 patients who underwent endoscopic intravariceal plus paravariceal injection lauromacrogol sclerotherapy. Then we observed the efficacy for emergency hemostasis and remission and complications of the endoscopic injection sclerotherapy (EIS). Results ①The efficacy of the therapy was associated with the times of therapies. The efficacy of therapy for every time was very significant (P≤0.001). The rate of esophageal varices remission was 96.55% (28/29) and that of recovery to G1 or disappeared was 82.76% (24/29) after four times of therapies. ②Success rate of emergency endoscopic hemostatis was 94.20% (65/69).③Thirteen patients with early rebleeding and 27 patients with late rebleeding, 4 patients had complications including 2 patients with esophageal mucosal erosion and bleeding and 2 patients with esophageal stenosis, they received treatments and recovered. Conclusion Endoscopic intravariceal plus paravariceal injection lauromacrogol sclerotherapy for treatment of esophageal varices was effective and safe, and the efficacy can be improved with more times of treatments and short intervals.

Key words: esophageal varices, lauromacrogol, endoscopic injection sclerotherapy, intravariceal and paravariceal