北京地区可疑过敏性鼻炎病人吸入性变应原特征分析

doi:10.3969/j.issn.1006-7795.2017.05.009

首都医科大学学报 ›› 2017, Vol. 38 ›› Issue (5): 671-676.doi: 10.3969/j.issn.1006-7795.2017.05.009

北京地区可疑过敏性鼻炎病人吸入性变应原特征分析

马思远¹, 娄鸿飞^1,2, 王成硕^1,2, 张罗^1,2

1. 首都医科大学附属北京同仁医院耳鼻咽喉头颈外科, 北京 100730;
2. 北京市耳鼻咽喉科研究所鼻病研究北京市重点实验室, 北京 100005

收稿日期:2017-07-07 出版日期:2017-09-21 发布日期:2017-10-18
通讯作者: 王成硕, 张罗 E-mail:wangcs830@126.com;dr.luozhang@139.com
基金资助:
国家自然科学基金重点项目（81630023），国家自然科学基金青年基金项目（81400444），国家自然科学基金面上项目（81470678），国家自然科学基金重点国际合作研究项目（81420108009），北京市医院管理局"使命"计划（SML20150203），北京市医院管理局"青苗"计划（QML20150202），首都临床特色应用研究（Z141107002514122），首都卫生发展科研专项重点攻关项目（2016-1-2052），北京市"百千万"人才项目（2016）。

Characteristic analysis of aeroallergens in Beijing patients suspicious of allergic rhinitis

Ma Siyuan¹, Lou Hongfei^1,2, Wang Chengshuo^1,2, Zhang Luo^1,2

1. Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China;
2. Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otorhinolaryngology, Beijing 100005, China

Received:2017-07-07 Online:2017-09-21 Published:2017-10-18
Supported by:
This study was supported by National Natural Science Foundation of China (81630023, 81400444, 81470678), National Science Fund for the Major International Joint Research Program (81420108009), Beijing Municipal Administration of Hospitals' Mission Plan (SML20150203), Beijing Municipal Administration of Hospitals' Youth Programme (QML20150202), Beijing Clinical Research Foundation (Z141107002514122), Capital Health Development Fundation(2016-1-2052), Talents Project of Beijing Municipal Human Resources and Social Security Bureau (2016).

摘要/Abstract

摘要： 目的回顾性分析可疑过敏性鼻炎（allergic rhinitis，AR）病人进行皮肤点刺试验（skin prick test，SPT）后吸入性变应原特征，为AR的临床诊疗提供帮助。方法对2011年1月1日至2013年7月31日就诊于首都医科大学附属北京同仁医院的北京地区2 598例具有AR典型症状的病人进行皮肤点刺试验，分析比较不同病人变应原检测结果差异。结果 1在2 598例可疑过敏性鼻炎受试者中，有2 292例（88.2%）病人至少对一种变应原有临床意义上的阳性。2在AR病人中，SPT检测阳性率前4位的变应原依次为：粉尘螨（43.1%）、屋尘螨（37.6%）、德国小蠊（32.6%）、艾蒿（26.6%）。就诊病人中女性居多，但SPT检测阳性率在性别间差异无统计学意义。3SPT检测阳性受试者中，单一变应原阳性（18.0%）、双重变应原阳性（22.6%）、三重变应原阳性（19.4%）占多数，未成年病人单一变应原阳性率较低。4AR就诊人数在4~6月和8~9月迎来两个高峰。5在单一变应原阳性病人中，德国小蠊阳性检出率（31.6%）远大于其他变应原。6粉尘螨、屋尘螨在不同年龄段变应原阳性检出率差异有统计学意义。结论粉尘螨、屋尘螨、德国小蠊、艾蒿是北京地区AR病人的主要变应原，变应原存在年龄及时间差异。

关键词: 过敏性鼻炎, 变应原, 流行病学, 皮肤点刺试验

Abstract: Objective To analyze the characteristics of the main inhaled allergens in patients suspicious of allergic rhinitis (AR) with skin prick test,and provide reference for the management of AR. Methods Skin prick test was performed on patients with typical symptoms of allergic rhinitis in Beijing Tongren hospital from Jan. 1, 2011 to Jul. 31, 2013. The result of the test in different people was compared. Results 1Of the 2 598 patients, 2 292(88.2%) had positive result with clinical significance。2The most common four allergens in patients with allergic rhinitis were Dermatophagoides farina (43.1%), Dermatophagoides pteronyssinus (37.6%), Blaterlia Germanica (32.6%) and Mugwort (26.6%). Most of the patients were female, but there was no significant difference in the positive rate between the genders. 3Patients with single positive allergen (18.0%), dual positive allergens (22.6%) and triple positive allergens (19.4%) were the most common. The patients before adult had low positive rate in single positive allergen group.4 There were two peaks for the number of patients from April to June and from August to September respectively.5 In single positive allergen group, the Blaterlia Germanica has a much higher positive rate (31.6%). 6 The positive rates of dust mites varied in different age groups. Conclusion Dermatophagoides farina, Dermatophagoides pteronyssinus, Blaterlia Germanica and Mugwort are the most common four allergens in patients with allergic rhinitis, different age groups and months had different allergen distributions.

Key words: allergic rhinitis, allergen, epidemiology, skin prick test

中图分类号:

R765.21

马思远, 娄鸿飞, 王成硕, 张罗. 北京地区可疑过敏性鼻炎病人吸入性变应原特征分析[J]. 首都医科大学学报, 2017, 38(5): 671-676.

Ma Siyuan, Lou Hongfei, Wang Chengshuo, Zhang Luo. Characteristic analysis of aeroallergens in Beijing patients suspicious of allergic rhinitis[J]. Journal of Capital Medical University, 2017, 38(5): 671-676.

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北京地区可疑过敏性鼻炎病人吸入性变应原特征分析

Characteristic analysis of aeroallergens in Beijing patients suspicious of allergic rhinitis

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