丙二醛、视黄醇与多囊卵巢综合征发病机制关系的探索

doi:10.3969/j.issn.1006-7795.2018.04.006

首都医科大学学报 ›› 2018, Vol. 39 ›› Issue (4): 512-516.doi: 10.3969/j.issn.1006-7795.2018.04.006

丙二醛、视黄醇与多囊卵巢综合征发病机制关系的探索

王虎生¹, 阮祥燕^1,2, 李扬璐¹, 程姣姣¹, 谷牧青¹, 杜娟¹, 金凤羽¹, Alfred O. Mueck^1,2

1. 首都医科大学附属北京妇产医院妇科内分泌科, 北京 100026;
2. 德国图宾根大学妇产医院妇女健康部与妇女健康研究中心, 图宾根 D-72076, 德国

收稿日期:2018-05-31 出版日期:2018-07-21 发布日期:2018-07-21
通讯作者: 阮祥燕 E-mail:ruanxiangyan@163.com
基金资助:
首都临床特色应用研究与成果推广（Z161100000516143），首都卫生发展科研专项项目（2016-2-2113），北京市医院管理局临床技术创新项目（XMLX201710），北京市卫生系统高层次卫生技术人才（学科带头人）（2014-2-016），北京市医院管理局"登峰"计划专项经费资助（DFL20181401）。

Exploration of relationship between malondialdehyde, retinol and pathogenesis of polycystic ovary syndrome

Wang Husheng¹, Ruan Xiangyan^1,2, Li Yanglu¹, Cheng Jiaojiao¹, Gu Muqing¹, Du Juan¹, Jin Fengyu¹, Alfred O. Mueck^1,2

1. Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China;
2. Department for Women's Health, University Women's Hospital and Research Center for Women's Health, University of Tuebingen, Tuebingen D-72076, Germany

Received:2018-05-31 Online:2018-07-21 Published:2018-07-21
Supported by:
This study was supported by Capital Characteristic Clinical Project of China(Z161100000516143), Beijing Capital Foundation for Medical Science Development and Research(2016-2-2113), Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (XMLX201710), Beijing Municipality Health Technology High-level Talent(2014-2-016), Beijing Municipal Administration of Hospitals' Ascent Plan (DFL20181401).

摘要/Abstract

摘要： 目的研究氧化应激指标丙二醛（malondialdehyde，MDA）、视黄醇（retinol，RET）与多囊卵巢综合征（polycystic ovary syndrome，PCOS）发病机制的关系。方法选取2017年7月至10月就诊于首都医科大学附属北京妇产医院内分泌科的PCOS患者65例作为研究组，同时选取因女方输卵管因素或男方因素而不孕或正常体检的健康育龄女性24例作为对照组。测量所有参与者的人体测量学指标、内分泌代谢指标及各氧化应激指标，比较PCOS患者与对照组各氧化应激指标特点。结果 PCOS组MDA、超氧化物歧化酶（superoxide dismutase，SOD）均显著高于对照组（P<0.05），血清RET浓度低于对照组（P<0.05）。PCOS组氧化型谷胱甘肽（oxidized glutathione，Glut oxyd，）、总抗氧化活性（total antioxidant activity，TAA）、维生素C（vitamin C，VC）、维生素E（vitamin E，VE）与对照组相比差异无统计学意义（P>0.05）。MDA与抗苗勒管激素（anti-Müllerian hormone，AMH）呈明显正相关（r=0.208，P=0.05），与睾酮（testosterone，TT）、空腹胰岛素（fasting insulin，FINS）、稳态胰岛素指数（homeostasis model assessment insulin resistance，HOMA-IR）无明显相关性（P>0.05）；RET与AMH呈明显负相关（r=-0.232，P<0.05），与TT、FINS、HOMA-IR无明显相关性（P>0.05）。结论多个氧化应激指标显示PCOS患者体内MDA代表的氧化应激水平增高，RET代表的抗氧化水平降低，深入研究氧化应激与PCOS的关系可能有助于阐明PCOS的发病机制。

关键词: 多囊卵巢综合征, 氧化应激, 丙二醛, 视黄醇, 发病机制

Abstract: Objective This study aims to investigate the relationship between oxidative stress indicators malondialdehyde (MDA), retinol (RET) and the pathogenesis of polycystic ovary syndrome(PCOS). Methods From July to October 2017, 65 cases of PCOS patients in Endocrinology Department of Beijing Gynecology Hospital, Capital Medical University were selected as study group and 24 healthy women who were infertile because of fallopian tube factor or male factor or normal physical examination were selected as control group at the same time. The anthropometric indexes, endocrine indexes, metabolic and oxidative stress indexes of all participants were measured. The characteristics of oxidative stress indicators were compared between PCOS patients and control group. Results Both MDA and superoxide dismutase (SOD) were significantly higher in PCOS group than those in control group (P<0.05), but the RET in PCOS group was significantly lower than that in control group (P<0.05). There was no significant difference in oxidized glutathione (Glut oxyd), total antioxidant activity (TAA), vitamin C (VC), vitamin E (VE) in the two groups (P>0.05). There was a positive correlation between MDA and anti-Müllerian hormone (AMH) (r=0.208, P=0.05) and there was no significant correlation between MDA and testosterone(TT), fasting insulin (FINS), and homeostasis model assessment insulin resistance (HOMA-IR) (P>0.05). There was a negative correlation between RET and AMH (r=-0.232, P<0.05), and there was no significant correlation between RET and TT, FINS, and HOMA-IR (P>0.05). Conclusion The study on multiple oxidative stress markers revealed that the oxidative stress level represented by MDA was increased and the antioxidant level represented by RET was decreased in PCOS patients. Further study of the relationship between oxidative stress and PCOS might be helpful to clarify the pathogenesis of PCOS.

Key words: polycystic ovary syndrome, oxidative stress, malondialdehyde, retinol, pathogenesis

中图分类号:

R711

王虎生, 阮祥燕, 李扬璐, 程姣姣, 谷牧青, 杜娟, 金凤羽, Alfred O. Mueck. 丙二醛、视黄醇与多囊卵巢综合征发病机制关系的探索[J]. 首都医科大学学报, 2018, 39(4): 512-516.

Wang Husheng, Ruan Xiangyan, Li Yanglu, Cheng Jiaojiao, Gu Muqing, Du Juan, Jin Fengyu, Alfred O. Mueck. Exploration of relationship between malondialdehyde, retinol and pathogenesis of polycystic ovary syndrome[J]. Journal of Capital Medical University, 2018, 39(4): 512-516.

参考文献

[1] Stein I F, Leventhal L M. Amenorrhea associated with bilateral polycystic ovaries[J]. Am J Obstet Gynecol, 1935,29:181-191.
[2] Fauser B C, Tarlatzis B C, Rebar R W, et al. Consensus on women's health aspects of polycystic ovary syndrome (PCOS):the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group[J]. Fertil Steril, 2012, 97(1):28-38.
[3] The Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome(PCOS)[J]. Hum Reprod, 2004, 19(1):41-47.
[4] Lizneva D, Suturina L, Walker W, et al. Criteria, prevalence, and phenotypes of polycystic ovary syndrome[J]. Fertil Steril, 2016,106(1):6-15.
[5] 中华医学会妇产科学分会内分泌学组及指南专家组. 多囊卵巢综合征中国诊疗指南[J]. 中华妇产科杂志,2018,53(1):2-6.
[6] 王虎生, 阮祥燕, 李雪, 等. 抗苗勒管激素与抑制素B对多囊卵巢综合征的临床预测价值[J].首都医科大学学报, 2017,38(4):492-497.
[7] Dursun F, Güven A, Yıldız M. Assessment of anti-Müllerian hormone level in management of adolescents with polycystic ovary syndrome[J]. J Clin Res Pediatr Endocrinol, 2016,8(1):55-60.
[8] Pawelczak M, Kenigsberg L, Milla S, et al. Elevated serum anti-Müllerian hormone in adolescents with polycystic ovary syndrome:relationship toultrasound features[J]. J Pediatr Endocrinol Metab, 2012,25(9-10):983-989.
[9] Cassar S, Teede H J, Moran L J, et al. Polycystic ovary syndrome and anti-Müllerian hormone:role of insulin resistance, androgens, obesity and gonadotrophins[J]. Clin Endocrinol (Oxf), 2014, 81(6):899-906.
[10] 付志红, 邢福棋. 活性氧与女性生殖[J]. 国外医学计划生育分册, 2005,24(3):107-109.
[11] Oyawoye O, Abdel Gadir A, Garner A, et al. Antioxidants and reactive oxygen species in follicular fluid of wowlen undergoing IVF:relationship to outcome[J]. Hum Reprod, 2003, 18(ii)l2270-2274.
[12] Carbone M C, Tatone C, Delle Monache S, et al. Antioxidant enzymatic defences in human folicular fluid:characterization and age-dependent changes[J]. Mol Hum Reprod, 2003, 9(11):639-643.
[13] Török A, Belagyi J, Török B, et al. Scaventger capacity of follicular fluid, decidua and culture medium with regard to assisted reproduction:an in vitro study using electron paramagnetic resonance spectroscopy[J].Gynecol Obstet Invest, 2003, 55(3):178-182.
[14] Seleem A K, El Refaeey A A, Shaalan D, et al. Superoxide dismutase in polycystic ovary syndrome patients undergoing intracytoplasmic sperm injection[J]. J Assist Reprod Genet,2014,31(4):499-504.
[15] Turan V, Sezer E D, Zeybek B, et al. Infertility and the presence of insulin resistance are associated with increased oxidative stress in young, non-obese Turkish women with polycystic ovary syndrome[J]. J Pediatr Adolesc Gynecol,2015,28(2):119-123.
[16] Murri M, Luque-Ramírez M, Insenser M, et al. Circulating markers of oxidative stress and polycystic ovary syndrome (PCOS):a systematic review and meta-analysis[J]. Human Reprod Update, 2013,19(3):268-288.
[17] Sugino N, Takiguchi S, Kashida S, et al. Superoxide dismutase expression in the human corpus luteum during the menstrual cycle and in early pregnancy[J]. Mol Hum Reprod, 2000, 6(1):19-25.
[18] 梅玲蔚, 熊正爱.氧化应激与多囊卵巢综合征的研究进展[J]. 广东医学, 2014, 35(8):1282-1284.
[19] Iliodromiti S, Kelsey TW, Anderson RA, et al.Can anti-Mullerian hormone predict the diagnosis of polycystic ovary syndrome? A systematic review and meta-analysis of extracted data[J].J Clin Endocrinol Metab,2013, 98(8):3332-3340.
[20] Özer A, Bakacak M, Kıran H, et al. Increased oxidative stress is associated with insulin resistance and infertility in polycystic ovary syndrome[J].Ginekol Pol,2016,87(11):733-738.
[21] Enli Y, Fenkci S M, Fenkci V, et al. Serum fetuin-a levels, insulin resistance and oxidative stress in women with polycystic ovary syndrome[J].Gynecol Endocrinol,2013,29(12):1036-1039.

丙二醛、视黄醇与多囊卵巢综合征发病机制关系的探索

Exploration of relationship between malondialdehyde, retinol and pathogenesis of polycystic ovary syndrome

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