首都医科大学学报 ›› 2022, Vol. 43 ›› Issue (4): 505-520.doi: 10.3969/j.issn.1006-7795.2022.04.001

• 专家述评 •    下一篇

加强脑静脉研究,提升神经系统疾病诊疗水平——脑静脉系统解剖、生理和临床概述

周一帆1 , 姜慧敏1, 卫慧敏2, 谷雨航3, 胡文伯4, 刘璐4 , 周陈1,4*, 吉训明1,5*   

  1. 1.首都医科大学脑重大疾病研究中心,北京 100069;
    2.北京航空航天大学大数据精准医疗高精尖中心,生物与医学工程学院,北京 100191;
    3.吉林大学中日联谊医院,长春 130033;
    4.首都医科大学宣武医院神经内科,北京 100053;
    5.首都医科大学宣武医院神经外科,北京 100053
  • 收稿日期:2022-05-26 出版日期:2022-08-21 发布日期:2022-10-28
  • 基金资助:
    北京市科技计划项目(Z181100001918026)。

Strengthening research on the cerebral venous system improves the diagnosis and treatment of neurological diseases——anatomy, physiology, and clinical overview

Zhou Yifan1, Jiang Huimin1, Wei Huimin2, Gu Yuhang3, Hu Wenbo4, Liu Lu4, Zhou Chen1,4*, Ji Xunming1,5*   

  1. 1. Beijing Institute of Brain Disorders of Capital Medical University, Beijing 100069, China;
    2. Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China;
    3. China-Japan Union Hospital of Jilin University, Changchun 130033, China;
    4. Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China;
    5. Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
  • Received:2022-05-26 Online:2022-08-21 Published:2022-10-28
  • Contact: *E-mail:chenzhou2013abc@163.com, jixm@ccmu.edu.cn
  • Supported by:
    This study was supported by Project of Beijing Science and Technology(Z181100001918026).

摘要: 大脑是人体内新陈代谢最旺盛的器官,需要丰富的血液供应以维持复杂的功能活动,人脑的血液供应分为动脉系统和静脉系统,脑动脉的病理生理机制已被深入的研究,然而,目前国际上对脑静脉的基础和临床研究经验较少。脑静脉系统容纳颅内70%~80%的血容量,在保证血流灌注及代谢废物的清除、血-脑脊液屏障的完整、颅内压调节、免疫监视甚至脑膜淋巴管功能等方面的重要作用陆续被报道。脑静脉系统作为新的研究领域,其在维持脑功能稳态和各种急慢性中枢神经系统疾病方面的病理生理作用也逐渐被重视。本综述概述了脑静脉系统的解剖引流和结构特征、脑静脉的生理功能以及在中枢神经系统疾病中的病理作用,旨在为全面认识脑静脉功能,科学认识与脑静脉相关的多种中枢神经系统疾病提供一定的借鉴。

关键词: 脑血管, 脑静脉, 脑静脉窦, 静脉窦血栓形成, 脑静脉回流障碍

Abstract: The brain is the most metabolically active organ in the human body, and it requires abundant blood supply to maintain complex functional activities. The blood supply of the human brain is divided into the arterial system and the venous system. The cerebral venous system holds 70%-80% of the intracranial blood volume,which plays an important role in ensuring blood perfusion and removing metabolic waste, maintaining the integrity of the blood-brain barrier, regulating intracranial pressure, immune monitoring, and even regulating the meningeal lymphatic function. As a new research field, cerebral venous system has attracted more and more attentions to its pathophysiological role in maintaining cerebral homeostasis and various acute/chronic central nervous system diseases. This review summarizes the anatomical drainage and structural characteristics of cerebral vein system, physiological functions of cerebral vein and its pathological role in central nervous system diseases, aiming to provide references for comprehensively scientific understanding of cerebral vein function and various central nervous system diseases.

Key words: cerebrovascular, cerebral vein, cerebral venous sinus, venous sinus thrombosis, cerebral venous reflux disorder

中图分类号: