首都医科大学学报 ›› 2022, Vol. 43 ›› Issue (6): 854-860.doi: 10.3969/j.issn.1006-7795.2022.06.006

• 核医学与分子影像辅助临床诊疗 • 上一篇    下一篇

18F-FDG PET/CT显像中连续采集和步进采集的比较

杨森, 王玲, 刘鹏, 金超岭, 李红磊, 富丽萍*   

  1. 中日友好医院核医学科,北京 100029
  • 收稿日期:2022-09-30 出版日期:2022-12-21 发布日期:2022-11-30
  • 基金资助:
    国家科技部重点研发计划数字诊疗专项(2016YFC0103804)。

Comparison of continuous-bed-motion and step-and-shoot acquisition modes on 18F-FDG PET/CT imaging

Yang Sen, Wang Ling, Liu Peng, Jin Chaoling, Li Honglei, Fu Liping*   

  1. Department of Nuclear Medicine, China-Japan Friendship Hospital, Beijing 100029, China
  • Received:2022-09-30 Online:2022-12-21 Published:2022-11-30
  • Contact: *E-mail:flp39@163.com

摘要: 目的 比较连续采集(continuous bed motion, CBM)和步进采集(step and shoot, SS)对18F-脱氧葡萄糖(fluorodeoxyglucose, FDG) 正电子发射型计算机断层显像/电子计算机断层显像(positron emission tomography/computed tomography,PET/CT)图像质量和定量分析的影响。 方法 选择50例PET/CT受检者分别采用CBM和SS模式在Siemens Biograph Vision 600 PET/CT设备中完成躯干部图像采集,测量纵隔血池、肺、肝、肌肉、骨骼的平均标准化摄取值(mean standardized uptake value, SUVmean)及标准差(standard deviation, SD),并用SD来评价图像噪声,采用配对t检验或配对秩和检验及Pearson相关分析和Bland-Altman图评价两组数据之间的差异和关系。 结果 在先后两次扫描中,纵隔血池和肝SUVmean显著降低(t =5.630和4.993,P <0.05),腰椎SUVmean显著增加(t =-3.320,P <0.05),而肺和肌肉SUVmean差异无统计学意义(P >0.05)。在不同进床模式中,所有组织SUVmean差异均无统计学意义(t =-1.626~-0.311,P >0.05),且存在高度相关(r=0.903~0.985),Bland-Altman图显示纵隔血池、肺、肝、竖脊肌、腰椎、大腿肌肉各组织的均值差分别为-0.02(95% CI:-0.27~0.24)、-0.01(95% CI:-0.05~0.03)、0.00(95% CI:-0.19~0.18)、-0.01(95% CI:-0.08~0.06)、-0.03(95% CI:-0.28 ~0.22)、0.00(95% CI:-0.07~0.08)。除大腿肌肉SD差异无统计学意义(Z =-1.163,P >0.05)外,其余各组织SSSD均小于CBMSD(Z =-4.406、-2.856、-5.556、-2.954和-3.104,P <0.05)。 结论 CBM采集方案灵活,能够提供与SS相当的定量信息,是PET/CT图像采集方法的有效补充。

关键词: 正电子发射型计算机断层显像术, 步进采集, 连续采集, 平均标准化摄取值

Abstract: Objective To investigate the effects of continuous-bed-motion (CBM) and step-and-shoot (SS) acquisition modes on image quality and quantitative analysis in 18F-FDG(fluorodeoxyglucose) PET/CT (positron emission tomography/computed tomography) . Methods A total of 50 patients were prospectively selected and undertake PET image acquisition in Siemens Biograph Vision 600 PET/CT equipment with CBM and SS modes. Mean standardized uptake value (SUVmean) and standard deviation (SD) of mediastinal blood pool, lung, liver, muscle, and bone were measured, and evaluate image noise with SD. Paired t test, Paired rank sum testPearson correlation analysis and Bland-Altman Figure were used to evaluate the difference and relationship between the data of two groups. Results In different acquisition sequences, the SUVmean of mediastinal bloodPool and liver were decreased significantly (t= 5.630 and 4.993, all P<0.05), the SUVmean of lumbar vertebra was increased significantly (t=-3.320, P<0.05), while the SUVmean of lung and muscle was not significantly different (all P>0.05). In different acquisition modes, there were no significant difference in SUVmean of all tissues (t values:from-1.626 to-0.311, P>0.05), and there were high correlation with them (r values: from 0.903 to 0.985),the Bland-Altman Figure shows that the mean difference of each tissues are-0.02(95%CI:-0.27 to 0.24), -0.01(95%CI:-0.05 to 0.03), 0.00(95%CI:-0.19 to 0.18), -0.01(95%CI:-0.08 to 0.06), -0.03(95%CI:-0.28 to 0.22),and 0.00(95%CI:-0.07 to 0.08). Except for the SD of thigh muscle (Z= -1.163, P>0.05), the SSSD of other tissues was lower than that of CBMSD (Z=-4.406, -2.856, -5.556, -2.954 and -3.104, all P<0.05). Conclusion CBM is a flexible acquisition method, which can provide the same quantitative information as SS. It is an effective supplement to PET/CT image acquisition method.

Key words: positron emission tomography, step-and-shoot mode, continuous-bed-motion mode, mean standardized uptake value

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