116例正常人房水中阿尔茨海默病生物标志物与年龄相关性研究

doi:10.3969/j.issn.1006-7795.2017.03.025

首都医科大学学报 ›› 2017, Vol. 38 ›› Issue (3): 461-464.doi: 10.3969/j.issn.1006-7795.2017.03.025

116例正常人房水中阿尔茨海默病生物标志物与年龄相关性研究

卢艳¹, 李臻², 吴越², 张健², 蒋惠中², 王宁利³

1. 首都医科大学附属北京世纪坛医院眼科, 北京 100038;
2. 首都医科大学宣武医院眼科, 北京 100053;
3. 首都医科大学附属北京同仁医院眼科, 北京 100730

收稿日期:2016-01-15 出版日期:2017-05-21 发布日期:2017-06-14
通讯作者: 卢艳 E-mail:louiselu1964@163.com
基金资助:
首都特色应用研究（Z141107002514116）。

Study of the correlation between biomarkers of Alzheimer's disease in aqueous humor and age in normal people

Lu Yan¹, Li Zhen², Wu Yue², Zhang Jian², Jiang Huizhong², Wang Ningli³

1. Department of Ophthalmology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China;
2. Department of Ophthalmology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China;
3. Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China

Received:2016-01-15 Online:2017-05-21 Published:2017-06-14
Supported by:
This study was supported by Capital Characteristic Clinic Project (Z141107002514116).

摘要/Abstract

摘要： 目的检测正常人房水中与阿尔茨海默病相关的生物标志物——淀粉样蛋白（β-amyloid protein，Aβ）、Tau蛋白和淀粉样前体蛋白（amyloid precursor protein，APP）与年龄的相关性。方法收集116例常规白内障手术病人房水，按照年龄分为：A组（年龄小于60岁，n=25），B组（年龄60~69岁，n=30），C组（年龄70~79岁，n=32），D组（年龄≥ 80岁，n=29），运用Ellisa方法检测样本中APP、Tau蛋白和Aβ40、Aβ42的浓度。结果不同年龄组房水中Aβ40、Aβ42、Tau蛋白和APP的浓度差异无统计学意义（P>0.05）。结论正常人房水中Aβ40、Aβ42、Tau蛋白和APP的浓度随年龄改变没有改变。

关键词: 正常人, 房水, 淀粉样蛋白, Tau蛋白, 淀粉样前体蛋白

Abstract: Objective To evaluate the correlation between biomarkers of Alzheimer's disease in aqueous humor and age in normal people. Biomarkers of Alzheimer's disease including amyloid β(Aβ), Tau protein, amyloid precursor protein(APP).Methods Aqueous humor was obtained from 116 patients undergoing routine cataract surgery and was divided into 4 groups as follows:A group (age<60 years old,n=25),B group (age from 60 to 69 years old, n=30),C group (age from 70 to 79 years old, n=32), D group (age ≥ 80 years old, n=29).Quantitative analysis of Aβ40,Aβ42,Tau protein, APP in the aqueous humor was evaluated via Elisa method.Results There was no significant difference in the expression levels of Aβ40,Aβ42, Tau, APP among the 4 groups(P>0.05).Conclusion The content of Aβ40,Aβ42, Tau, APP in aqueous humor had no association with age in normal people.

Key words: normal people, aqueous humor, β-amyloid protein, Tau protein, amyloid precursor protein

中图分类号:

R331.5⁺6

卢艳, 李臻, 吴越, 张健, 蒋惠中, 王宁利. 116例正常人房水中阿尔茨海默病生物标志物与年龄相关性研究[J]. 首都医科大学学报, 2017, 38(3): 461-464.

Lu Yan, Li Zhen, Wu Yue, Zhang Jian, Jiang Huizhong, Wang Ningli. Study of the correlation between biomarkers of Alzheimer's disease in aqueous humor and age in normal people[J]. Journal of Capital Medical University, 2017, 38(3): 461-464.

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116例正常人房水中阿尔茨海默病生物标志物与年龄相关性研究

Study of the correlation between biomarkers of Alzheimer's disease in aqueous humor and age in normal people

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