关键词: 糖化血红蛋白指数, 糖化血红蛋白, 颈动脉斑块, 心血管代谢风险

Abstract: Objective To investigate the association between hemoglobin glycation index (HGI) and carotid plaques in a large cohort in China.Methods The study recruited participants who underwent physical examinations from April 2016 to August 2021 in Beijing Chaoyang Hospital, Capital Medical University. Fasting blood glucose and hemoglobin A1c (HbA1c) were utilized to calculate the formula of the HGI. The HGI was categorized according to terciles (Q1, Q2, Q3), with Q1 as the reference.  Logistic regression was applied to explore the predictive factors of carotid plaques.Results There were 1 106 participants in the study. Subjects in the highest tercile of HGI had the largest percentage of people who were older than 45 years old. They also showed the most severe metabolic risks, including a higher percentage of hypertension, hyperlipidemia, diabetes, a higher level of total cholesterol, triglyceride, low density lipoprotein-cholesterol, and HbA1c. Participants in the highest tercile of HGI had the largest percentage of people with carotid plaques (Q1∶Q2∶Q3: 23.8%  vs  23.9%  vs  39.6%, P<0.001). After the adjustment of age, gender, body mass index (BMI), hypertension, hyperlipidemia, diabetes, estimated glomerular filtration rate (eGFR), and uric acid, there were 1.47 (95%CI: 0.98－2.20, P=0.06) and 1.66 (95%CI: 1.14－2.43, P=0.008) times higher odds of having carotid plaques among people in the medium and the highest HGI terciles respectively, compared to people in the lowest tercile of HGI.Conclusions Increased HGI was associated with various cardiometabolic risk factors and was an independent predictor of carotid plaques. A calculation of HGI may help to evaluate the personalized risk for cardiometabolic diseases.

Key words: hemoglobin glycation index, glycated hemoglobin A1c, carotid artery plaque, cardiometabolic risk