血清维生素A、E与2型糖尿病老年人认知功能的分析

doi:10.3969/j.issn.1006-7795.2023.06.023

首都医科大学学报 ›› 2023, Vol. 44 ›› Issue (6): 1060-1066.doi: 10.3969/j.issn.1006-7795.2023.06.023

血清维生素A、E与2型糖尿病老年人认知功能的分析

高妍彦，任修文，王玺翔，徐京晶，马骁骏，刘璐，刘宇，苑林宏^*

首都医科大学公共卫生学院，北京 100069

收稿日期:2023-03-24 出版日期:2023-12-21 发布日期:2023-12-21
通讯作者: 苑林宏 E-mail:ylhmedu@126.com
基金资助:
国家自然科学基金项目（81973027，82173508)，北京高层次公共卫生技术人才培养计划项目（2022-3-032)。

Correlation between serum vitamin A and vitamin E and cognitive function in aging subjects with type 2 diabetes mellitus

Gao Yanyan, Ren Xiuwen, Wang Xixiang, Xu Jingjing, Ma Xiaojun, Liu Lu, Liu Yu, Yuan Linhong^*

School of Public Health, Capital Medical University, Beijing 100069, China

Received:2023-03-24 Online:2023-12-21 Published:2023-12-21
Supported by:
This study was supported by National Natural Science Foundation of China（81973027，82173508），Beijing High-level Public Health Technical Personnel Training Program（2022-3-032).

摘要/Abstract

摘要： 目的探讨血清维生素A、维生素E浓度与2型糖尿病（type 2 diabetes mellitus, T2DM)老年人认知功能的相关性。方法募集社区60岁以上T2DM老年人500例。同时募集年龄、性别、受教育程度与T2DM患者相匹配的非糖尿病60岁以上健康居民500例作为对照组。采用自行设计调查表对研究对象进行社会人口学、生活方式、疾病史等因素调查。应用蒙特利尔认知评估量表（Montreal Cognitive Assessment, MoCA)对被调查者的认知功能进行评估。采集被调查者的空腹静脉血，用于检测空腹血糖（fasting blood glucose, FBG)、血总胆固醇（total cholesterol, TC)、三酰甘油（triglyceride, TG)、低密度脂蛋白胆固醇（low density lipoprotein-cholesterol, LDL-C)和高密度脂蛋白胆固醇（high density lipoprotein-cholesterol, HDL-C)等生物化学指标。高效液相色谱法对血清中维生素A（vitamin A, VA)和维生素E（vitamin E, VE)进行检测。采用SPSS 20.0对数据进行统计分析。结果T 2DM组中，认知功能正常者血清VA浓度（0.59 μg/mL)高于患有轻度认知功能障碍（mild cognitive impairment, MCI)者（0.50 μg/mL)，差异有统计学意义（P<0.01)；认知功能正常者血清VE含量（12.22 μg/mL)高于MCI患者（11.40 μg/mL)，但差异无统计学意义（P >0.05)。糖尿病患者血清VA浓度与MoCA总分及各项评分（除定向功能外)均呈正相关；较高浓度的血清VA浓度与低浓度相比，患糖尿病的风险降低（OR<1，P<0.05)。结论本研究观察到较高的血清VA浓度与更好的认知功能有关，所以较高的血清VA浓度可能作为T2DM老年人认知功能的一种保护性因素；而血清VE浓度与老年人认知功能尚不能得出存在关联性的结论。

关键词: 糖尿病, 维生素A, 维生素E, 认知功能

Abstract: Objective To investigate the correlation between serum vitamin A and vitamin E levels and cognitive function in aging subjects in older adults with type 2 diabetes mellitus (T2DM). Methods A total of 500 T2DM patients were recruited from Communities. And 500 age, gender and education level matched non-diabetic healthy adults were recruited as normal control subjects. A self-designed questionnaire was used to investigate socio-demography, lifestyle, disease history and other factors. Montreal Cognitive Assessment (MoCA) scale was used to assess the cognitive function. Fasting venous blood was collected for biochemical parameters including fasting blood glucose (FBG), total blood cholesterol (TC), triglycerides (TG), low density lipoprotein-cholesterol (LDL-C) and high density lipoprotein-cholesterol (HDL-C) levels. The serum levels of vitamin A (VA) and vitamin E (VE) were detected by high performance liquid chromatography (HPLC). SPSS 20.0 was used to statistically analyze the data. ResultsAmong the T2DM group, the serum VA level of those with normal cognitive function (0.59 μg/mL) was higher than that of those with mild cognitive impairment (MCI) (0.50 μg/mL), and the difference was statistically significant (P<0.01). The serum VE level of those with normal cognitive function (12.22 μg/mL) were higher than those with MCI (11.40 μg/mL), but the difference was no statistically significance (P>0.05). Serum VA levels in T2DM group were positively correlated with the total MoCA score and all scores (except the orienting function); and higher concentrations of serum VA levels were associated with a reduced risk of developing diabetes compared with lower levels (OR<1, P<0.05). Conclusion In this study, we found that higher serum VA levels were associated with better cognitive function. Thus, higher serum VA levels may act as a protective factor for cognitive function in elderly with T2DM. However, there is no association between serum VE level and cognitive function in the elderly.

Key words: diabetes, vitamin A, vitamin E, cognitive function

中图分类号:

高妍彦, 任修文, 王玺翔, 徐京晶, 马骁骏, 刘璐, 刘宇, 苑林宏. 血清维生素A、E与2型糖尿病老年人认知功能的分析[J]. 首都医科大学学报, 2023, 44(6): 1060-1066.

Gao Yanyan, Ren Xiuwen, Wang Xixiang, Xu Jingjing, Ma Xiaojun, Liu Lu, Liu Yu, Yuan Linhong. Correlation between serum vitamin A and vitamin E and cognitive function in aging subjects with type 2 diabetes mellitus[J]. Journal of Capital Medical University, 2023, 44(6): 1060-1066.

参考文献

［1］WHO. Dementia［R/OL］. ［2021－06－08］. https://www.who.int/news-room/fact-sheets/detail/dementia.
［2］Jia L F, Quan M N, Fu Y, et al. Dementia in China: epidemiology, clinical management, and research advances［J］. Lancet Neurol, 2020, 19(1): 81－92.
［3］Raghow R. Metabolic balancing acts of vitamin A in type-2 diabetes and obesity［J］. World J Diabetes, 2012, 3(10): 174－177.
［4］Dong W L, Zhang Y K. Retinoic acid receptor α expression exerts an anti-apoptosis effect on PC12 cells following oxygen-glucose deprivation［J］. Exp Ther Med, 2018, 16(4): 3525－3533.
［5］Joshi Y B, Praticò D. Vitamin E in aging, dementia, and Alzheimer's disease［J］. Biofactors, 2012, 38(2): 90－97.
［6］Kryscio R J, Abner E L, Caban-Holt A, et al. Association of antioxidant supplement use and dementia in the prevention of Alzheimer's disease by vitamin E and selenium trial (PREADViSE)［J］. JAMA Neurol, 2017, 74(5): 567－573.
［7］Kandimalla R, Thirumala V, Reddy P H. Is Alzheimer's disease a type 3 diabetes? A critical appraisal［J］. Biochim Biophys Acta Mol Basis Dis, 2017, 1863(5): 1078－1089.
［8］ Lu J, Li D, Li F, et al. Montreal cognitive assessment in detecting cognitive impairment in Chinese elderly individuals: a population-based study［J］. J Geriatr Psychiatry Neurol,2011,24(4):184-190.
［9］Winblad B, Palmer K, Kivipelto M, et al. Mild cognitive impairment-beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment［J］. J Intern Med, 2004, 256(3): 240-246.
［10］Meerza D, Iqbal S, Zaheer S, et al. Retinoids have therapeutic action in type 2 diabetes［J］. Nutrition, 2016, 32(7/8): 898－903.
［11］Mody N. Alterations in vitamin A/retinoic acid homeostasis in diet-induced obesity and insulin resistance［J］. Proc Nutr Soc, 2017, 76(4): 597－602.
［12］Browne D, McGuinness B, Woodside J V, et al. Vitamin E and Alzheimer's disease: what do we know so far?［J］. Clin Interv Aging, 2019, 14: 1303－1317.
［13］Kumar R R, Singh L, Thakur A, et al. Role of vitamins in neurodegenerative diseases: a review［J］. CNS Neurol Disord Drug Targets, 2022, 21(9): 766－773.
［14］Zeng J Y, Chen L, Wang Z, et al. Marginal vitamin A deficiency facilitates Alzheimer's pathogenesis［J］. Acta Neuropathol, 2017, 133(6): 967－982.
［15］Bloom G S, Lazo J S, Norambuena A. Reduced brain insulin signaling: a seminal process in Alzheimer's disease pathogenesis［J］. Neuropharmacology, 2018, 136(Pt B): 192－195.
［16］Soria Lopez J A, González H M, Léger G C. Alzheimer's disease［J］. Handb Clin Neurol, 2019, 167: 231－255.
［17］Blaner W S. Vitamin a signaling and homeostasis in obesity, diabetes, and metabolic disorders［J］. Pharmacol Ther, 2019, 197: 153－178.
［18］Meerza D, Iqbal S, Zaheer S, et al. Retinoids have therapeutic action in type 2 diabetes［J］. Nutrition, 2016, 32(7/8): 898－903.
［19］Biyong E F, Tremblay C, Leclerc M, et al. Role of retinoid X receptors (RXRs) and dietary vitamin a in Alzheimers disease: evidence from clinicopathological and preclinical studies［J］. Neurobiol Dis, 2021, 161: 105542.
［20］Shudo K, Fukasawa H, Nakagomi M, et al. Towards retinoid therapy for Alzheimer's disease［J］. Curr Alzheimer Res, 2009, 6(3): 302－311.
［21］Handing E P, Small B J, Andel R, et al. Can nutrition or inflammation moderate the age-cognition association among older adults?［J］. J Gerontol B Psychol Sci Soc Sci, 2019, 74(2): 193－201.
［22］McBurney M I, Yu E A, Ciappio E D, et al. Suboptimal serum α-tocopherol concentrations observed among younger adults and those depending exclusively upon food sources, NHANES 2003-20061-3［J］. PLoS One, 2015, 10(8): e0135510.
［23］Stover P J, Garza C, Durga J, et al. Emerging concepts in nutrient needs［J］. J Nutr, 2020, 150(Suppl 1): 2593S－2601S.
［24］Rafnsson S B, Dilis V, Trichopoulou A. Antioxidant nutrients and age-related cognitive decline: a systematic review of population-based cohort studies［J］. Eur J Nutr, 2013, 52(6): 1553－1567.
［25］Takasaki J, Ono K, Yoshiike Y, et al. Vitamin a has anti-oligomerization effects on amyloid-β in vitro［J］. J Alzheimers Dis, 2011, 27(2): 271－280.

[1]	冯晓彤, 柯静, 朱琳, 赵冬. 糖尿病视网膜病变的病理生理学研究进展[J]. 首都医科大学学报, 2023, 44(3): 420-423.
[2]	刘畅, 郭默宁, 袁颖超, 郑建鹏, 杨金奎. 2013至2018年北京地区1型糖尿病发病率性别差异及预测[J]. 首都医科大学学报, 2023, 44(3): 370-374.
[3]	李雨阳, 朱晓蓉, 刘婧, 郑晓敏, 杨金奎, 杨芳远. 糖尿病肾病患者触珠蛋白基因多态性及血清触珠蛋白浓度分析[J]. 首都医科大学学报, 2023, 44(3): 375-380.
[4]	郑晓敏, 李彬, 刘翠平, 周迎生, 崔丽梅. 老年2型糖尿病患者黎明现象的分析和对策[J]. 首都医科大学学报, 2023, 44(3): 400-406.
[5]	李明嘉, 赵苗妙, 杨金奎. 组织蛋白酶在糖尿病及糖尿病肾病作用机制中的研究进展[J]. 首都医科大学学报, 2023, 44(3): 413-419.
[6]	夏宁, 聂秀红, 王美平, 冯志红, 穆志静, 樊晓君. 阻塞性睡眠呼吸暂停与单纯鼾症患者的睡眠效率与糖尿病患病率的相关性研究[J]. 首都医科大学学报, 2023, 44(3): 487-496.
[7]	马玉茹, 袁仙仙, 郑薇, 刘程, 王佳, 李光辉. 妊娠早期血清游离脂肪酸水平与妊娠期糖尿病的关系[J]. 首都医科大学学报, 2023, 44(2): 265-271.

血清维生素A、E与2型糖尿病老年人认知功能的分析

Correlation between serum vitamin A and vitamin E and cognitive function in aging subjects with type 2 diabetes mellitus

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 7

编辑推荐

Metrics

本文评价