肠道菌群与糖尿病、炎症因子及C反应蛋白的因果关系——孟德尔随机化分析

doi:10.3969/j.issn.1006-7795.2024.03.017

首都医科大学学报 ›› 2024, Vol. 45 ›› Issue (3): 488-493.doi: 10.3969/j.issn.1006-7795.2024.03.017

肠道菌群与糖尿病、炎症因子及C反应蛋白的因果关系——孟德尔随机化分析

胡亚芬¹, 华琳^2*

1.首都医科大学大兴教学医院内分泌科，北京 102600;2.首都医科大学生物医学工程学院智能医学工程学学系，北京 100069

收稿日期:2024-02-29 出版日期:2024-06-21 发布日期:2024-06-13
通讯作者: 华琳 E-mail:hualin7750@ccmu.edu.cn

The causal relationship between intestinal flora and diabetes, inflammatory factors and C-reactive protein: Mendelian randomized analysis

Hu Yafen¹, Hua Lin^2*

1.Department of Endocrinology, Daxing District People's Hospital, Capital Medical University, Beijing 102600，China; 2.Department of Intelligent Medical Engineering, School of Biomedical Engineering, Capital Medical University, Beijing 100069，China

Received:2024-02-29 Online:2024-06-21 Published:2024-06-13

摘要/Abstract

摘要： 目的探索糖尿病与肠道菌群失调以及炎症因子和C反应蛋白的相关性。方法将肠道菌群作为暴露因素，糖尿病、炎症因子和C反应蛋白作为结局因素，以单核苷酸多态性(single nucleotide polymorphisms, SNPs)作为工具变量，采用孟德尔随机化分析方法探讨肠道菌群与糖尿病、炎症因子和C反应蛋白的关系。结果粪球菌、戴阿利斯特杆菌、毛螺菌和吉氏拟杆菌等在糖尿病人群中丰度相对较低，而嗜胆菌和罗姆布茨菌在糖尿病人群中丰度相对较高。戴阿利斯特杆菌与白介素-17（interleukin-17，IL-17）相关(β=0.797,P=0.036)。C反应蛋白与粪球菌(β＝－0.036,P=0.027)、吉氏拟杆菌(β＝－0.216,P=0.015)和戴阿利斯特杆菌 (β＝－0.028,P=0.030)均呈负相关。对于粪球菌和吉氏拟杆菌与糖尿病的关系，C反应蛋白存在中介效应。结论本研究结果提示肠道菌群、C反应蛋白和糖尿病存在潜在的相互作用。

关键词: 肠道菌群, 糖尿病, 炎症因子, C-反应蛋白, 孟德尔随机化

Abstract: Objective To explore the relationship between intestinal flora and diabetes mellitus, inflammatory factors and C-reactive protein (CRP).Methods In this study, the intestinal flora was taken as exposure factors while diabetes, inflammatory factors and CRP were taken as outcome factors, and single nucleotide polymorphisms（SNPs） were used as instrument variables. Mendelian randomization method was used. Results Coprococcus1, Dialister, Lachnospiraceae and Parabacteroides were less abundant in the diabetes population whereas Bilophila and Romboutsia were more abundant in the diabetes population. Dialister is positively correlated with interleukin-17（IL-17） (β=0.797, P=0.036). CRP is negatively correlated with Coprococcus1 (β＝－0.036, P=0.027), Parabacteroides (β＝－0.216, P=0.015), and Dialister (β＝－0.028, P=0.030). CRP showed the mediation effect in the relationship between two bacteria (Coprococcus1 and Parabacteroides) and diabetes.Conclusion Our study suggests the potential interactions between intestinal flora, CRP and diabetes.

Key words: intestinal flora mellitus, diabetes mellitus, inflammatory factors, C-reactive protein, Mendelian randomization

中图分类号:

R587.1

胡亚芬, 华琳. 肠道菌群与糖尿病、炎症因子及C反应蛋白的因果关系——孟德尔随机化分析[J]. 首都医科大学学报, 2024, 45(3): 488-493.

Hu Yafen, Hua Lin. The causal relationship between intestinal flora and diabetes, inflammatory factors and C-reactive protein: Mendelian randomized analysis[J]. Journal of Capital Medical University, 2024, 45(3): 488-493.

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肠道菌群与糖尿病、炎症因子及C反应蛋白的因果关系——孟德尔随机化分析

The causal relationship between intestinal flora and diabetes, inflammatory factors and C-reactive protein: Mendelian randomized analysis

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