首都医科大学学报 ›› 1987, Vol. 8 ›› Issue (2): 109-112.

• 论著 • 上一篇    下一篇

罗布麻浸膏对麻醉犬的血液动力学影响

董忠田, 候欣荣, 赵淑芬   

  1. 首都医学院药理学教研室
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:1987-04-15 发布日期:1987-04-15

Effects of Apocynum Extract on Haemodynamics in Anesthetized Open-chest Dogs

Dong Zhongtian   

  1. Department of Pharmacology
  • Received:1900-01-01 Revised:1900-01-01 Online:1987-04-15 Published:1987-04-15

摘要: 给麻醉狗静脉恒速注射罗布麻叶浸膏水滤液(10%、2.0mL/kg、3.6mL/min)后,血压下降持续7分钟以上,下降最大达22.3%,血压下降同时伴有心率减慢(r=0.83),但心率减慢自给药后持续30分钟。血压降低同时CO、CI、SI及LCF减少。对心脏前后负荷无影响。静脉注射后3分钟内见心肌耗氧量减少。

关键词: 罗布麻, 血流动力学, 血压, 降压药

Abstract: Administration of 10% Apocynum extract by iv.(2.0mL/kg,3.6mL/min) induced the significant reduction of BP(22.3%)which continued more than7 minutes and related with a reduction of H.R.(r=0.83)and continued more than 30 min.The CO,CI,SI,LCF were decreased while decreasing blood pressure.The decrease of myocardic O2 consumption were observed within 3 minutes after Apocynum extract administration.

Key words: apocynum, hemodynamics, blood pressure, antihypertensive drug