急性多发性神经根神经炎外周血T淋巴细胞亚群的研究

首都医科大学学报 ›› 1990, Vol. 11 ›› Issue (3): 191-194.

急性多发性神经根神经炎外周血T淋巴细胞亚群的研究

赵跃然¹, 王美玲¹, 李辉², 高天祥²

1. 山东省医学科学研究所;2. 首都医学院细胞生物学教研室

收稿日期:1989-02-15 修回日期:1900-01-01 出版日期:1990-07-15 发布日期:1990-07-15

Study of T Lymphocyte Subsets in Acute Polyradiculoneuritis

Zhao Yueran¹, Wang Meiling¹, Li Hui², Gao Tianxiang²

1. Shandong Medical Scientific Institute;2. Department of Cell Biology, Capital Institute of Medicine Meiling

Received:1989-02-15 Revised:1900-01-01 Online:1990-07-15 Published:1990-07-15

摘要/Abstract

摘要： 用抗人T细胞单克隆抗体OKT₃、OKT₄,OKT₈检测急性多发性神经根神经炎(AP)患者T淋巴细胞细胞亚群。共检测AP患者23例,正常对照20例,并观察不同病情、病型患者的T细胞亚群的改变。结果表明AP患者OKT_a⁺、KT₄⁺细胞百分率与正常对照组相同,但OKT₈⁺细胞百分率明显低于对照组(p<0.05),OKT₄⁺/OKT_a⁺细胞比率相应升高(pa⁺细胞和OKT₄⁺/OKT₈⁺细胞比率逐渐恢复正常。结果提示细胞免疫紊乱可能在AP发病中有重要作用。

关键词: 急性多发性神经根神经炎, 人T淋巴细胞, 单克隆抗体, 间接免疫荧光

Abstract: Ficol-Hypaque separated peripheral bloo dmononuclear cells were analysed by indirect immunofluorescence assay with ortho monoclonal antibodies to T cells (OKT₃⁺), helper cells (OKT₄⁺) and suppressor cytotoxic cells (OKT₈⁺). 20 normal subjects and 23 patients with acute polyradiculoneuritis (AP) wore studied, The percentages of OKT₃⁺ and OKT₄⁺ cells were similar in the 2 groups, but the percentages of OKT₈⁺ cells was reduced to 18.96±4.24 compared with 22.28±3.15 in the the normal subjects (p <0.05). The ratio of OKT₄⁺/OKT₈⁺ cells was correspondingly increased to 2.38±0.55, compared with 1.97±0.20 in the normal subjects. These changes fell towards normal with the passage of time. The result suggests that AP might be an autoimmunity disease with cell immunity disorders.

Key words: acute polyradiculoneuritis, human T lymphocyte, monoclonal antibodies, indirect immunofluorescence assay

赵跃然;王美玲;李辉;高天祥. 急性多发性神经根神经炎外周血T淋巴细胞亚群的研究[J]. 首都医科大学学报, 1990, 11(3): 191-194.

Zhao Yueran;Wang Meiling;Li Hui;Gao Tianxiang. Study of T Lymphocyte Subsets in Acute Polyradiculoneuritis[J]. Journal of Capital Medical University, 1990, 11(3): 191-194.

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