KA8肽对酒精所致大鼠胃粘膜损伤的保护作用

首都医科大学学报 ›› 1994, Vol. 15 ›› Issue (1): 38-40.

KA8肽对酒精所致大鼠胃粘膜损伤的保护作用

赵咏梅, 王霄虹, 董士勤, 盛树力

首都医学院宣武医院

收稿日期:1992-10-28 修回日期:1900-01-01 出版日期:1994-01-15 发布日期:1994-01-15

Protective Effect of KA8 Peptide on Ethanol-induced Gastric Mucosal Erosion in Rat

Zhao Yongmei, Wang Xiaohong, Dong Shiqin, Sheng Shuli

Institute of Geriatrics, Xuanwu Hospital, Capital Institute of Medicine

Received:1992-10-28 Revised:1900-01-01 Online:1994-01-15 Published:1994-01-15

摘要/Abstract

摘要：

采用经胃管给禁食大鼠注入1mL纯酒精造成胃粘膜损伤的方法,观察预先给予KA8肽对胃粘膜的保护作用,实验结果表明,注入1mL纯酒精1h后,大鼠胃粘膜损伤严重,面积广泛.皮下注射KA8肽30、60μg/kg体重均可使酒精所致大鼠胃粘膜损伤明显减轻,损伤面积较对照组明显减少(P<0.01).由此推断,KA8肽对胃粘膜具有细胞保护作用.

关键词: KA8肽, 酒精, 胃粘膜损伤, 细胞保护作用

Abstract:

KA8 peptide is a C-terminal octapeptide(30～37)of oxyntomodulin 1～37. We previously reported that it could inhibit gastric acid secretion of rat induced by pentagastrin, cold-restraint and intracisteral TRH obviously. In our experiment ,KA8 peptide was injected to rats at a dose of 30 μg/kg body weight or 60 μg/kg body weight before 1 mL absolute ethanol was given to the animals through a gastric tube. The results showed that KA8 peptide could decrease ethanol-induced gastric erosion significantly, compared with control(P<0.01). It suggests that KA8 peptide could have cytoprotective effect on gastric mucosa, and it might be beneficial in the treatment of a variety of diseases in which gastric mucosal injury is present.

Key words: KA8 peptide, ethanol, gastric mucosal erosion, cytoprotective effect

中图分类号:

R335

赵咏梅;王霄虹;董士勤;盛树力. KA8肽对酒精所致大鼠胃粘膜损伤的保护作用[J]. 首都医科大学学报, 1994, 15(1): 38-40.

Zhao Yongmei;Wang Xiaohong;Dong Shiqin;Sheng Shuli. Protective Effect of KA8 Peptide on Ethanol-induced Gastric Mucosal Erosion in Rat[J]. Journal of Capital Medical University, 1994, 15(1): 38-40.

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