慢性丙型肝炎患者外周血T淋巴细胞亚群的检测

首都医科大学学报 ›› 1994, Vol. 15 ›› Issue (2): 119-122.

慢性丙型肝炎患者外周血T淋巴细胞亚群的检测

宋小平, 陈祖贵, 闵福援, 冷强, 孙丽梅, 吴昊, 林秀玉, 汪俊韬

北京佑安医院

收稿日期:1993-01-09 修回日期:1900-01-01 出版日期:1994-04-15 发布日期:1994-04-15

Detection of Lymphocyte Subsets in Peripheral Blood of Patients with Hepatitis C

Song Xiaoping, Chen Zugui, Min Fuyuan, Leng Qiang, Sun Limei, Wu Hao, Lin Xiuyu, Wang Juntao

Beijing Youan Hospital

Received:1993-01-09 Revised:1900-01-01 Online:1994-04-15 Published:1994-04-15

摘要/Abstract

摘要： 应用单克隆抗体和APAAP法对35例慢性丙型肝炎患者的外周血T淋巴细胞亚群的分布进行了检测.结果表明慢性丙肝患者OKT₃⁺;细胞与正常对照无显著差异,而OKT₄⁺、OKT₈⁺细胞及OKT₄,/OKT₈.比值均低于正常对照.结果还表明HBsAg阴性的丙肝患者OKT₄⁺细胞和OKT₄/OKT8.比值明显低于正常对照,而OKT₃⁺细胞差别不显著.合并HBsAg阳性的丙肝患者OKT₄⁺、OKT₈⁺细胞均显著低于正常对照和慢性活动性乙型肝炎患者,而OKT₄/OKT₈.比值的差异则不显著,OKT₈⁺细胞还显著低于HBsAg阴性的丙肝患者.提示慢性丙型肝炎患者外周血T淋巴细胞亚群分布存在明显的失衡现象,合并HBsAg阳性对OKT₈⁺细胞有明显影响.

关键词: 丙型肝炎, 慢性乙型肝炎, T淋巴细胞亚群, 单克隆抗体

Abstract: T cell subsets in peripheral blood of 35 chronic patients with hepatitis C have been investigated through monoclonal antibody and APAAP assay. The results showed that the percentage of OKT3⁺ cells in patient group with hepatitis C had no difference and OKT₄⁺,OKT₈⁺ cells and OKT₄/OKT₈ ratio were lower than that of the control group.The percentage of OKT₄⁺ cells and OKT₄/OKT₈ ratio in HBsAg negative patient group with hepatitis C were significantly lower than that of the control group. No difference was observed in the percentage of OKT₈ cells. The percentages of OKT₄⁺,OKT₈⁺cells in HBsAg positive patient group with hepatitis C were significantly lower in comparison with control group and chronic active patient group with hepatitis B, but the OKT₄/OKT₈ ratio showed no difference. The percentage of OKT₈⁺ cells was significantly lower as compared with HBsAg negative patient group with hepatitis C. These results indicated that T cell subsets in peripheral blood in patients with hepatitis C were obviously out of balance and the percentage of OKT₈⁺ cells was significantly lower in hepatitis C patients co-infected with HBV.

Key words: hepetitis C, hepatitis B, T cell subsets, monoclonal antibody

中图分类号:

R512.6

宋小平;陈祖贵;闵福援;冷强;孙丽梅;吴昊;林秀玉;汪俊韬. 慢性丙型肝炎患者外周血T淋巴细胞亚群的检测[J]. 首都医科大学学报, 1994, 15(2): 119-122.

Song Xiaoping;Chen Zugui;Min Fuyuan;Leng Qiang;Sun Limei;Wu Hao;Lin Xiuyu;Wang Juntao. Detection of Lymphocyte Subsets in Peripheral Blood of Patients with Hepatitis C[J]. Journal of Capital Medical University, 1994, 15(2): 119-122.

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