人Hrs cDNA的克隆与序列分析

首都医科大学学报 ›› 1997, Vol. 18 ›› Issue (3): 238-241.

人Hrs cDNA的克隆与序列分析

卢令格¹, 驹田雅之², 喜多村直实²

1. 首都医科大学附属北京友谊医院北京市临床医学研究所;2. 日本关西医科大学肝脏研究所

收稿日期:1996-06-04 修回日期:1900-01-01 出版日期:1997-07-15 发布日期:1997-07-15

Cloning and Sequence Analysis of Human Hrs cDNA

Lu Lingge¹, Masayuki Komada², Naomi Kitamura²

1. Research Institute of Clinical Medicine, Beijing Friendship Hospital, Affiliate of Capital University of Medical Sciences;2. Institute for Liver Research, Kansai Medical University, Japan

Received:1996-06-04 Revised:1900-01-01 Online:1997-07-15 Published:1997-07-15

摘要/Abstract

摘要： 以小鼠HrscDNA为探针从人胎盘cDNA文库中克隆出人HrscDNA,其全长为2910bp,所编码的蛋白质含777个氨基酸。人HrscDNA与小鼠HrscDNA间高度保守。推定的氨基酸序列含有锌指样结构域、脯氨酸丰富区及脯氨酸、谷氨酰胺丰富区。

关键词: 人Hrs, 分子克隆, 核苷酸序列

Abstract: The human Hrs cDNAwas cloned from human placenta library. It was 2910 bp in length encoding a protein of 777 amino acids with a calculated molecular weight of 85550.Comparison of human Hrs cDNAand deduced amino acid sequence with their mouse couterpart, it shared homo logy of 85% in nucleotid sequence and 92.5% in amino acids sequence, respectively. The human Hrs also contained a zinc finger like domain, a proline rich region and a proline and glutamine rice region.

Key words: human Hrs, molecular cloning, nucleotide sequence

中图分类号:

Q523
Q753

卢令格;驹田雅之;喜多村直实. 人Hrs cDNA的克隆与序列分析[J]. 首都医科大学学报, 1997, 18(3): 238-241.

Lu Lingge;Masayuki Komada;Naomi Kitamura. Cloning and Sequence Analysis of Human Hrs cDNA[J]. Journal of Capital Medical University, 1997, 18(3): 238-241.

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