首都医科大学学报 ›› 1997, Vol. 18 ›› Issue (4): 348-349.

• 论著 • 上一篇    下一篇

高血压病患者脂类代谢与纤溶系统的变化及意义

高国静, 华琦, 何士大   

  1. 首都医科大学宣武医院内科
  • 收稿日期:1997-06-01 修回日期:1900-01-01 出版日期:1997-10-15 发布日期:2013-10-28

Clinical Significance of Serum Lipoprotein,Apolipoprotein and Lipid Levels and Marker of Thrombin Activation in Patients with Essential Hypertension

Gao Guojing, Hua Qi, He Shida   

  1. Department of Internal Medicine, Xuanwu Hospital, Affiliate of Capital University of Medical Sciences
  • Received:1997-06-01 Revised:1900-01-01 Online:1997-10-15 Published:2013-10-28

摘要: 为探讨高血压病与动脉粥样硬化的相关关系,观察了25例高血压病患者与20例健康人脂类代谢与纤溶系统的变化。发现高血压组较对照组载脂蛋白A、纤溶酶元及组织型纤溶酶元激活物明显下降(P<0.001及0.05),氧化型低密度脂蛋白及纤溶酶元激活物抑制剂明显升高(P<0.05及0.001),提示高血压病是致动脉粥样硬化的重要危险因素之一。

关键词: 高血压病, 脂代谢, 纤溶系统, 动脉粥样硬化

Abstract: For investigating the relationship between essential hypertension and atherosclerosis,metabolism of lipids and marker of thrombin activation in 25 patients with essential hypertension and 20 normal subjects were observed. It was found that apoAand PGAwere significant lower and PAIwere significant higher in hypertension group than in control group (P <0.001 and 0.01),there was positive correlation between systolic hypertension and oxLDL (P <0.01). It is suggested that essential hypertension is one of the important dangerous factors in inducing atherosclerosis.

Key words: essential hypertension, lipoprotein, thrombin activation, atherosclerosis

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