电针对大鼠脑局部缺血-再灌流损伤的保护作用

首都医科大学学报 ›› 1998, Vol. 19 ›› Issue (3): 217-220.

电针对大鼠脑局部缺血-再灌流损伤的保护作用

张学勤¹, 左大鹏¹, 王秋萍¹, 赵毅², 高玉红², 耿稚萍², 陈志强³

1. 首都医科大学附属北京同仁医院检验科;2. 首都医科大学附属北京同仁医院神经内科;3. 北京中医药大学针灸系

收稿日期:1997-09-22 修回日期:1900-01-01 出版日期:1998-07-15 发布日期:1998-07-15

Protective Effects of Electro-Acupuncture on Focal Cerebral Ischemia Reperfusion Injury in Rats

Zhang Xueqin¹, Zuo Dapeng¹, Wang Qiuping¹, Zhao Yi², Gao Yuhong², Geng Zhiping², Chen Zhiqiang³

1. Department of Clinical Laborotary, Tongren Hospital, Affiliate of Capital University of Medical Sciences;2. Department of Neurology, Tongren Hospital, Affiliate of Capital University of Medical Sciences;3. Department of Acupuncture Beijing Chinese Traditional Medical College

Received:1997-09-22 Revised:1900-01-01 Online:1998-07-15 Published:1998-07-15

摘要/Abstract

摘要： 再灌流前电针“环跳”穴30min,观察对左大脑中动脉(MCA)缺血再灌流模型大鼠早期运动功能、自由基代谢、脑水肿及神经电生理活动的影响。结果:缺血再灌+针刺组大鼠再灌流后神经功能缺损状况有较明显的改善,病灶侧脑组织过氧化物歧化酶(SOD)活性及丙二醛(MDA)含量恢复到接近假手术对照组的水平。皮层体感诱发电位(SEP)测量表明缺血侧P1潜伏期及P1-N1波幅亦有显着性改善。结果表明:于再灌流前电针处理对本模型脑缺血再灌流损伤有保护作用.

关键词: 再灌流损伤, 自由基, 皮层体感诱发电位, 电针

Abstract: Using a rat model of reversible regional cerebral ischemia, the effects of electro-acupuncture were examined at the point of “huantiao” before reperfusion. The left middle cerebral artery(MCA)occlusion was achieved with a nylon filament placed into the vessel. The results showed that animals in the acupuncture treatment group had a significantly regaining of movement ability than that in the ischemia reperfusion group. The mean levels of malondialdehyde(MDA)concentration and superoxide dismutase(SOD)activity of the ischemic hemisphere in the acupuncture treatment group returned to the level of sham control group. The cortical somatosensory evoked potentials(SEP)measured ipsilaterally on the cortex of ischemic hemisphere showed that with electro acupuncture,both P1 latency and P1-N1 amplitude improved significantly. The results suggested that electro-acupuncturing at the point of “huantiao” has beneficial effects on focal cerebral ischemia-reperfusion injury in rats.

Key words: reperfusion injury, free radical, SEP, electro-acupuncture

中图分类号:

R743.3

张学勤;左大鹏;王秋萍;赵毅;高玉红;耿稚萍;陈志强. 电针对大鼠脑局部缺血-再灌流损伤的保护作用[J]. 首都医科大学学报, 1998, 19(3): 217-220.

Zhang Xueqin;Zuo Dapeng;Wang Qiuping;Zhao Yi;Gao Yuhong;Geng Zhiping;Chen Zhiqiang. Protective Effects of Electro-Acupuncture on Focal Cerebral Ischemia Reperfusion Injury in Rats[J]. Journal of Capital Medical University, 1998, 19(3): 217-220.

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