首都医科大学学报 ›› 1998, Vol. 19 ›› Issue (4): 352-354.

• 论著 • 上一篇    下一篇

老年NIDDM患者微量白蛋白尿与脂质代谢的关系及临床意义

钱玉英, 陈秉良   

  1. 首都医科大学宣武医院综合科
  • 收稿日期:1997-12-04 修回日期:1900-01-01 出版日期:1998-10-15 发布日期:1998-10-15

Serum Lipids and Lipoproteins in Elder NIDDM Patients with Microalbuminuria

Qian Yuying, Chen Bingliang   

  1. General Department of Xuanwu Hospital, Affiliate of Capital University of Medical Sciences
  • Received:1997-12-04 Revised:1900-01-01 Online:1998-10-15 Published:1998-10-15

摘要: 为了研究老年非胰岛素依赖型糖尿病(NIDDM)患者尿微量白蛋白与血脂、脂蛋白的关系,测定了老年NIDDM伴微量白蛋白尿(UAE)患者和NIDDM不伴UAE患者及正常对照组的甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白A(apoA)、载脂蛋白B(apoB)、脂蛋白(a)〔LP(a)〕.结果:老年NIDDM伴有微量蛋白尿患者的TG、Lp(a)显着高于不伴UAE的NIDDM患者及对照组,而apoA及HDL-C明显低于不伴UAE的NIDDM患者及对照组.结果提示:老年NIDDM伴有微量白蛋白尿患者的心血管病的发病率及死亡率的增加可能与血脂及脂蛋白代谢异常有关.

关键词: 老年人, 非胰岛素依赖型糖尿病, 微量白蛋白尿, 血脂, 脂蛋白

Abstract: To study the relationship of slight albuminuria(microalbuminuria)to serum lipids and lipoproteins in elder NIDDM, the levels of plasma TC、TG、HDL-C、apoA、apoB、Lp(a)were determined in elder NIDDM patients with microalbuminuria and normal albuminuria and control subjects. The result showed that the levels of plasma TG Lp(a)in elder NIDDM patients with microalbuminuria were significantly higher than those in elder NIDDM patients with normal albuminuria and control subjects. The levels of plasma HDL-C、 apoA in elder NIDDM patients with microalbuminuria were significantly lower than those in elder NIDDM patients with normal albuminuria and control subjects. It is conclude that elder NIDDM patients with microalbuminuria are associated with alter lipid and lipoprotein levels. The excess cardiovascular mortality and morbidity in elder NIDDM patients with microalbuminuria may. In part, be explained by these lipidand lipoprotein abnormalities.

Key words: aged, non-insulin dependent diabetes mellitus, microalbuminuria, serum lipid, lipoprotein

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