脑缺血及再灌注对血液粘度与红细胞变形性的影响

首都医科大学学报 ›› 2001, Vol. 22 ›› Issue (1): 6-9.

脑缺血及再灌注对血液粘度与红细胞变形性的影响

丁库克¹, 曾衍钧², 廖东华², 胡金麟³, 宋欣³

1. 首都医科大学研究生部;2. 北京工业大学生物医学工程中心;3. 中国人民解放军总医院

收稿日期:1999-12-18 修回日期:1900-01-01 出版日期:2001-01-15 发布日期:2001-01-15

Effect of Cerebral Post-ischemia Reperfusion on Blood Viscosity and Erythrocyte Deformation

Ding Kuke¹, Zeng Yanjun², Liao Donghua², Hu Jinlin³, Song Xin³

1. Postgraduate Office, Capital University of Medical Sciences;2. Biomedical Engineering Center, Beijing Polytechnic University;3. General Hospital of PLA

Received:1999-12-18 Revised:1900-01-01 Online:2001-01-15 Published:2001-01-15

摘要/Abstract

摘要： 利用大鼠脑缺血及再灌注模型,探讨血液粘度、红细胞变形性指标(DI)在脑缺血及再灌注情况下的变化.实验表明:在缺血过程中,主要由于RBC的代偿作用,全血粘度减低,RBC变形性增强;在再灌注过程中,全血与血浆的粘度都升高,到再灌注12h发现有恢复正常的趋势;说明在缺血、缺氧情况下,三磷腺苷减少及一些化学因子的释放促使了这种改变,长时间的再灌注会起到修复作用.随着切变率的增加,同组实验组中DI的测量值均呈指数函数递增,对此建立该模型下的数学方程:φ=a+b×e^[-c(x-x₀)];同时对同一切变率不同实验组的RBC变形性也做了研究,发现DI变化不仅与缺氧及代谢性酸中毒有关,而且与RBC自身的特性有关.

关键词: 缺血及再灌注, 血液流变学, 红细胞变形性, 血液粘度, 切变率

Abstract: The rat model of cerebral post-ischemia reperfusion was employed in the experiment to explore whether the values of indicator of blood viscosity and erythrocyte deformation had significant difference between the experimental groups and the control group. It was found that the blood viscosity declined during ischemia, mainly because of the compensation of RBC. During reperfusion viscosity of both blood and serum increased, but there was a tendency for viscosity to return to the normal level at the point of 12 h after onset of reperfusion. These results indicate that the reduction of ATP and the release of some chemical factors during ischemia induced the change. Long time reperfusion can compensate for it. With the increase of shear rate, the erythrocyte deformation increased exponentially and the math equation of this model was set up at the same shear rate: φ= a+b×e^[-c(x-x₀)]. It was found that erythrocyte deformation varied greatly. This is not only related to its ischemia and acidosis, but the biological character of RBC is involved.

Key words: post-ischmia reperfusion, hemorheology, RBC deformation, blood viscosity, shear rate

中图分类号:

R364.1

丁库克;曾衍钧;廖东华;胡金麟;宋欣. 脑缺血及再灌注对血液粘度与红细胞变形性的影响[J]. 首都医科大学学报, 2001, 22(1): 6-9.

Ding Kuke;Zeng Yanjun;Liao Donghua;Hu Jinlin;Song Xin. Effect of Cerebral Post-ischemia Reperfusion on Blood Viscosity and Erythrocyte Deformation[J]. Journal of Capital Medical University, 2001, 22(1): 6-9.

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