去白细胞滤器在血液科干细胞移植病房应用的研究

首都医科大学学报 ›› 2001, Vol. 22 ›› Issue (4): 340-342.

去白细胞滤器在血液科干细胞移植病房应用的研究

李燕郴, 陈世伦, 刘晋伟, 王慧娟

首都医科大学附属北京红十字朝阳医院血液科

收稿日期:2000-11-18 修回日期:1900-01-01 出版日期:2001-10-15 发布日期:2001-10-15

Using Leukocyte Reduction Filter in the Stem Cell Transplantation Unit of the Department of Hematology

Li Yanchen, Chen Shilun, Liu Jinwei, Wang Huijuan

Department of Hematology, Beijing Chaoyang Hospital, Affiliate of Capital University of Medical Sciences

Received:2000-11-18 Revised:1900-01-01 Online:2001-10-15 Published:2001-10-15

摘要/Abstract

摘要： 为评价去白细胞滤器在血液科干细胞移植病房使用的有效性和安全性,分别观察了11例外周血干细胞移植患者使用去白细胞滤器输血时去除白细胞的效果、红细胞或血小板的回收率、输血相关的移植物抗宿主病(TAGVHD)和其他输血反应的发生情况.结果:使用去白细胞滤器可以将残留白细胞控制在10⁵以内,能够有效避免TA-GVHD的发生.其他输血反应的发生率也由未使用去白细胞滤器时的37.8%(20/53)降至15.0%(6/40),P<0.005.提示:去白细胞滤器可以安全地应用于干细胞移植病房.

关键词: 去白细胞滤器, 输血, 造血干细胞移植

Abstract: The study evaluated the effectiveness and safety of using the leukocyte reduction filter in the stem cell transplantation unit of the department of hematology. The filters were used in 11 patients who were treated with peripheral blood stem cell transplantation. The effectiveness of the leukocyte reduction, the recovery of the red cell or pletlet were measured. The occurance of TA-GVHD and the other reaction of transfusion were observed. By using the filters, white cells could be controlled within 10 5, and TA-GVHD could be efficiently avoided. The reaction rate of transfusion was reduced from 37.8%(20/53)which did not use the filters in general ward to 15.0%(6/40, P<0.005). Leukocyte reduction filter could be safely used in the stem cell transplantation of the hema tological department.

Key words: leukocyte reduction filter, transfusion, stem cell transplantation

中图分类号:

R730.59
R733

李燕郴;陈世伦;刘晋伟;王慧娟. 去白细胞滤器在血液科干细胞移植病房应用的研究[J]. 首都医科大学学报, 2001, 22(4): 340-342.

Li Yanchen;Chen Shilun;Liu Jinwei;Wang Huijuan . Using Leukocyte Reduction Filter in the Stem Cell Transplantation Unit of the Department of Hematology[J]. Journal of Capital Medical University, 2001, 22(4): 340-342.

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