首都医科大学学报 ›› 2002, Vol. 23 ›› Issue (2): 113-114.

• 基础研究 • 上一篇    下一篇

冷应激大鼠血浆及回肠P物质和VIP的变化

李利生, 曲瑞瑶, 郭华, 王伟, 孟阳   

  1. 首都医科大学生理学教研室
  • 收稿日期:2001-12-11 修回日期:1900-01-01 出版日期:2002-04-15 发布日期:2002-04-15

Changes of SP and VIP in Blood and Ileum of Cool Stress Rats

Li Lisheng, Qu Ruiyao, Guo Hua, Wang Wei, Meng Yang   

  1. Department of Physiology, Capital University of Medical Sciences
  • Received:2001-12-11 Revised:1900-01-01 Online:2002-04-15 Published:2002-04-15

摘要: 采用放免法对冷束缚应激大鼠血浆及回肠始段P物质(SP)、血管活性肠肽(VIP)进行测定。发现与正常对照组相比,应激组回肠段SP含量无明显改变,VIP含量降低(P<0.05);应激组血浆中SP质量浓度明显增加(P<0.01),VIP质量浓度则明显降低(P<0.01).提示:应激组大鼠回肠始段及血浆SP、VIP的改变,可能与其胃肠功能变化的调节有关。

关键词: 应激, P物质(SP), 血管活性肠肽(VIP)

Abstract: Substance P(SP)and vasoactive intestinal peptide(VIP)levels in blood and all layers of initial part of ileum in rats were measured by radioimmunoassays(RIA)in order to explore the mechanism of cool stress. SP levels in ileum of cool stress didn't change while the VIP levels in ileum of cool stress were significantly lower than the controls groups(P<0.05). SP levels in blood of cool stress were significantly higher(P<0.01)while the VIP levels in blood of cool stress were significantly lower than the controls groups(P<0.01). The results shows that changes of SP and VIP levels in the initial part ileum and blood of cool stress may be related to the gastrointestinal motility disorders presented in cool stress rats.

Key words: stress|substance P(SP)|vasoactive intestinal peptide(VIP)

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