儿茶提取物抗流感病毒作用的小鼠体内实验研究

首都医科大学学报 ›› 2004, Vol. 25 ›› Issue (1): 32-34.

儿茶提取物抗流感病毒作用的小鼠体内实验研究

郑群, 平国玲, 赵文明

首都医科大学微生物学教研室

收稿日期:2003-03-29 修回日期:1900-01-01 出版日期:2004-01-15 发布日期:2004-01-15

Anti-influenza Effect of Catechu Extract in Mice

Zheng Qun, Ping Guoling, Zhao Wenming

Department of Microbiology, Capital University of Medical Sciences

Received:2003-03-29 Revised:1900-01-01 Online:2004-01-15 Published:2004-01-15

摘要/Abstract

摘要： 用流感病毒鼠肺适应株A/FM/1/47(H1N1)感染小鼠,制备小鼠肺炎模型,研究儿茶提取物对流感病毒感染小鼠死亡的保护作用。结果显示:高剂量组对感染小鼠具有很好的死亡保护作用(P<0.05),高、中剂量组均可明显延长感染小鼠的平均存活时间。高剂量组(12.5g/L)的肺指数、肺指数抑制率和肺病变程度与阳性药物(病毒唑)对照组相比均有显著性差异(P<0.05)。研究表明:该儿茶提取物在小鼠体内具有有效的抗流感病毒作用.

关键词: 儿茶, 流感病毒, 小鼠肺炎模型

Abstract: The objective was to investigate the anti-influenza effect of catechu extract, w hich was tested on murine pneumonia model by influenza virus strain A/FM/1/47(H1 N1). The results showed 12.5 g/L of catechu extract had significant effect on in fluenza virus strain A/FM/1/47(H1N1) (P< 0.05). The survival time in the gro up of mice infected with influenza virus was markedly prolonged and the patholog ic changes of the murine lung was improved significantly at the concentration of 12.5 g/L, compared to the control murine group fed with ribavirin. The fin dings suggest that the catechu extract has a strong anti-influenza effect.

Key words: catechu extract, influenza virus, murine pneumonia model

中图分类号:

R373

郑群;平国玲;赵文明. 儿茶提取物抗流感病毒作用的小鼠体内实验研究[J]. 首都医科大学学报, 2004, 25(1): 32-34.

Zheng Qun;Ping Guoling;Zhao Wenming. Anti-influenza Effect of Catechu Extract in Mice[J]. Journal of Capital Medical University, 2004, 25(1): 32-34.

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