关键词: 卡维地洛, 比索洛尔, 慢性心力衰竭, 6min步行距离, 心脏功能

Abstract: Objective To compare the efficacies of carvedilol,bisoprolol and conventional therapies for patients with chronic heart failure(CHF).Methods we assigned 92 patients with CHF to three groups,one was conventional therapies group(n=20) treated with ACE inhibitor+digoxin+diuretic,the other two groups were carvedilol group(n=34) and bisoprolol group((n=)38) treated respectively with carvedilol or bisoprolol in addition to the above regular treatment.All the patients were followed up for six months and measured respectively the changes of heart rate,blood pressure,6 minutes walking distance and cardiac function by echocardiography.Results 1) After treatment,the heart rate,blood pressure and myocardial oxygen consumption of the patients in the carvedilol group and bisoprolol group all decreased significantly compared with those of conventional group.In the meantime 6 minutes walking distance increased,but no significantly.2) After treatment,LVEDD and LVESD were smaller in the carvedilol group and bisoprolol group than those in conventional group,and LVEF was higher than that in conventional group.LVESD was smaller in the carvedilol group than that in the bisoprolol group.Conclusion Carvedilol and bisoprolol can further reverse the remodelling of left ventricle and improve cardiac function through their β₁ receptors blocking function.The clinical efficacies of Carvedilol and bisoprolol were similar.

Key words: carvedilol, bisoprolol, chronic heart failure, 60min walk, cardiac function