关键词: 急性冠状动脉综合征, 血浆妊娠相关蛋白A, 高敏C反应蛋白, 基质金属蛋白酶9, 主要不良心血管事件

Abstract:

Objective The aim of the present study is to assess the value of hs-CRP,PAPP-A and MMP-9 in diagnosis and to evaluate the short-term prognosis of ACS.Methods Sixty patients with ACS and 30 patients without ACS were enrolled in this study.The hs-CRP PAPP-A MMP-9 levels were measured.Patients with ACS were followed up for 30 days after admission.The relation between these three factors and the 30 days prognosis were observed.Results Blood hs-CRP levels showed significant differences between control and unstable angina(UA) groups(P<0.05),control and acute myocardial infarction(AMI) groups)P<0.01),as well as UA and AMI groups(P<0.01).There were very significant differences in blood PAPP-A and MMP-9 levels(P<0.01).Blood hs-CRP was positively correlated with blood PAPP-A and MMP-9.Single factor analysis showed all the three levels were higher in MACE patients(P<0.01).Logistic regression analysis showed that blood PAPP-A and MMP-9 were correlated with MACE in 30 days(P<0.05).Conclusion Because the hs-CRP,PAPP-A and MMP-9 might decrease the stability of the plaque,they are important risk factors of ACS.Inflammation affected the development and changes of ACS by decreasing the stability of the plaque.The levels of hs-CRP PAPP-A and MMP-9 are correlated with the short-term prognosis of ACS.PAPP-A and MMP-9 levels are independent risk factors of short-term prognosis in ACS patients.PAPP-A and MMP-9 could be better predictors than hs-CRP.

Key words: acute coronary syndrome(ACS), pregnancy-associated plasma protein-A(PAPP-A), high-sensitivity Creactive protein(hs-CRP), matrix metalloproteinase-9(MMP-9), main adverse cardiovascular event(MACE)