血管新生因子与酶在多发性骨髓瘤不同临床阶段中的变化

首都医科大学学报 ›› 2007, Vol. 28 ›› Issue (6): 763-765.

血管新生因子与酶在多发性骨髓瘤不同临床阶段中的变化

杨光忠, 陈文明, 刘晋玮

首都医科大学附属北京朝阳医院血液内科, 北京市多发性骨髓瘤医疗研究中心

收稿日期:2007-03-14 修回日期:1900-01-01 出版日期:2007-12-24 发布日期:2007-12-24

Changes of Angiogenic Factors in Different Clinical Stages of Multiple Myeloma

Yang Guangzhong, Chen Wenming, Liu Jinwei

Department of Hematology, Beijing Chaoyang Hospital, Capital Medical University

Received:2007-03-14 Revised:1900-01-01 Online:2007-12-24 Published:2007-12-24

摘要/Abstract

摘要： 目的比较多发性骨髓瘤(multiple myeloma,MM)患者不同临床阶段骨髓中血管新生因子与酶的水平,分析血管新生因子与酶在病情演变中的变化。方法选取66例MM患者和14例意义未明的单克隆免疫球蛋白病(MGUS)患者为研究对象。所有研究对象均进行骨髓穿刺。应用ABC-ELISA法测定骨髓中血管新生因子与酶(IL-6、VEGF、bFGF、MMP-2、MMP-9)的水平。结果新诊断MM患者与复发/难治MM患者的骨髓血管新生因子与酶水平无明显差异,均高于缓解患者与MGUS;MGUS患者除MMP-9低于缓解MM患者外,其余细胞因子与酶水平与缓解患者无明显差异。结论 MM患者骨髓中血管新生因子与酶水平与其病情正相关,测定血管新生因子与酶的浓度可以用来评价患者的病情。

关键词: 多发性骨髓瘤, 血管新生, 血管新生因子

Abstract: Objective To analyze the changes of angiogenic factors during the development of MM in different clinical stages.Methods Sixty-six MM patients and 14 monoclonal gammopathy patients of undetermined significance(MGUS) were studied.Five-milliliter of bone marrow,anticoagulate with heparin,were obtained from each patient.The levels of angiogenic factors(IL-6,VEGF,bFGF,MMP-2,MMP-9) in BM were determined with ABC-ELISA.Results There was no difference in angiogenic factors between the newly diagnosed and refractory/relapsed MM,but they were higher than MM at remission and MGUS.There was no difference in angiogenic factors except for MMP-9 between MM at remission and MGUS.Conclusion The levels of angiogenic factors in bone marrow of MM patients are positively correlated with the patient's condition.Determinations of the concentrations of angiogenic factors are useful for the evaluation of the disease course.

Key words: multiple myeloma, angiogenesis, angiogenic factors

中图分类号:

R551.3

杨光忠;陈文明;刘晋玮. 血管新生因子与酶在多发性骨髓瘤不同临床阶段中的变化[J]. 首都医科大学学报, 2007, 28(6): 763-765.

Yang Guangzhong;Chen Wenming;Liu Jinwei . Changes of Angiogenic Factors in Different Clinical Stages of Multiple Myeloma[J]. Journal of Capital Medical University, 2007, 28(6): 763-765.

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