TF、TFPI、t-PA、PAI-1在DIC和DIC前期的检测及意义探讨

首都医科大学学报 ›› 2008, Vol. 29 ›› Issue (2): 146-148.

TF、TFPI、t-PA、PAI-1在DIC和DIC前期的检测及意义探讨

段朝霞, 杨林花

山西省人民医院血液科

收稿日期:2008-01-18 修回日期:1900-01-01 出版日期:2008-04-24 发布日期:2008-04-24
通讯作者: 杨林花

Investigation of TF,TFPI,t-PA and PAI-1 in Patients pre DIC and DIC and Their Significance

Duan Zhaoxia, Yang Linhua

Department of Hemotology, the Second Hospital of Shanxi Medical University

Received:2008-01-18 Revised:1900-01-01 Online:2008-04-24 Published:2008-04-24

摘要/Abstract

摘要： 目的观察凝血和纤维蛋白溶解系统在弥漫性血管内凝血(disseminated intravascular coagulation,DIC)前期和DIC期的变化,为早期发现和治疗DIC提供依据.方法 ELISA 法检测DIC前期、DIC期、非DIC患者血浆组织因子(tissue factor,TF)和组织因子途径抑制物(tissue factor pathway inhibitor,TFPI),组织型纤维蛋白酶原活化剂(tissue type plasminogen activator,t-PA)及其抑制物PAI-1(plasminogen activator inhibitor-1)和D-二聚体浓度.比较TF/TFPI和t-PA/PAI-1比值.结果在DIC发生发展过程中,TF、TFPI、t-PA、PAI-1和D-二聚体均增高,DIC前期TF/TFPI比值增高,DIC期t-PA/PAI-1比值增高.结论 DIC的发生发展与凝血系统和纤维蛋白溶解系统失平衡有关,DIC前期TFPI对TF抑制不足可能是DIC凝血和血栓形成的主要原因,TF/TFPI可以作为DIC前期指标,提示有DIC趋势;DIC的出血可能主要与PAI-1对t-PA 抑制不足继发纤维蛋白溶解亢进相关,该研究可为今后应用抗纤维蛋白溶解药物治疗DIC提供理论依据.

关键词: 组织因子, 组织因子途径抑制物, 组织型纤溶酶原激活物, 纤溶酶原激活物抑制物-1, 弥漫性血管内凝血

Abstract: Objective To investigate the changes of coagulation and fibrinolysis systems during pre-DIC and DIC, and determine the relationships among TF and TFPI as well as t-PA and PAI-1. Methods Plasma concentrations of TF, TFPI, t-PA, PAI-1 and D-Dimer were measured with ELISA and ratios of TF/TFPI and t-PA/PAI-1 obtained. Results TF, TFPI, t-PA, PAI-1 and D-Dimer all became higher during the progress of DIC, TF/TFPI ratio was higher in pre-DIC, and t-PA/PAI-1 ratio was higher in DIC. Conclusion DIC is related to the disorders of coagulation and fibrinolysis system. Unbalance of TF and TFPI may be the cause of thrombosis formation in DIC; while the unbalance of t-PA and PAI-1 may be the most important cause of serious bleeding during DIC.

Key words: tissue factor, tissue factor pathway inhibitor, tissue type plasminogen activator, plasminogen activator inhibitor-1, disseminated intravascular coagulation

中图分类号:

R554⁺.8

段朝霞;杨林花. TF、TFPI、t-PA、PAI-1在DIC和DIC前期的检测及意义探讨[J]. 首都医科大学学报, 2008, 29(2): 146-148.

Duan Zhaoxia;Yang Linhua. Investigation of TF,TFPI,t-PA and PAI-1 in Patients pre DIC and DIC and Their Significance[J]. Journal of Capital Medical University, 2008, 29(2): 146-148.

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