关键词: 多脏器功能障碍综合征, 动物模型, 组织氧代谢

Abstract: Objective To investigate the characteristics of the tissue oxygenation changes in the MODS animal model.Methods Sixteen one-year-old male swines weighting was 20～25 kg were involved.Bacilius(17 million/kg) was injected into the right jugular vein,the tissue oxygenation-index(arterial oxygen content,CaO₂,oxygen delivery,DO₂,oxygen consumption,VO₂,oxygen delivery index,DO₂I,oxygen consumption index,VO₂I,oxygen extraction rate,O₂Ext) were determined at 1 h,3 h,5 h,7 h after injection.Results The study showed that,DO₂,VO₂ had no remarkably difference after 1,3,5 hours of Colon bacillus injection,after 7 hours have no remarkably difference compared with that was before making mode(P<0.01),but DO₂I,VO₂I had very remarkably difference compared with that was before making mode(P<0.01),after 1,3,5,7hours of Colon bacillus injection.After 5,7 hours injected Colon bacillus,the extract rate of oxygen(O₂Ext) had remarkable difference(P<0.05).With linear correlation analysis for DO₂I-VO₂I,it was found DO₂I was remarkably linear correlated with VO₂I(r=0.784,P<0.01),therefore,they had the dependent relation.Conclusion These findings provide the experimental basis for the clinical study of MODS.

Key words: MODS, animal model, tissue oxygenation