胶质瘤组织MGMT和Ki-67表达对患者预后的影响

doi:10.3785/j.issn.1006-7795.2009.03.006

首都医科大学学报 ›› 2009, Vol. 30 ›› Issue (3): 285-288.doi: 10.3785/j.issn.1006-7795.2009.03.006

胶质瘤组织MGMT和Ki-67表达对患者预后的影响

徐丽¹, 崔云², 李桂林², 江涛³

1. 首都医科大学附属北京市神经外科研究所分子病理室;2. 首都医科大学附属北京市神经外科研究所神经病理室;3. 首都医科大学附属北京天坛医院神经外科

收稿日期:2009-03-18 修回日期:1900-01-01 出版日期:2009-06-21 发布日期:2009-06-21
通讯作者: 江涛

Association Between the Expression of O6-Methylguanine-DNA Methyltransferase and Ki-67 in Glioma Tissues and Prognosis of Patients with Glioma

XU Li¹, CUI Yun², LI Gui-lin², JIANG Tao³

1. Department of Molecular Pathology, Beijing Neurosurgical Institute, Capital Medical University;2. Department of Neuropathology, Beijing Neurosurgical Institute, Capital Medical University;3. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University

Received:2009-03-18 Revised:1900-01-01 Online:2009-06-21 Published:2009-06-21

摘要/Abstract

摘要： 目的研究胶质瘤组织MGMT和Ki-67的表达,探讨其对患者预后的影响。方法总结79 例脑胶质瘤患者的性别、年龄、术前Karnofsky评分、无进展生存期和生存期等; 将患者手术切除标本石蜡切片进行Ki-67和MGMT 的免疫组化染色,计算染色阳性率;多元逐步回归分析法判断Ki-67和MGMT的表达与患者无进展生存时间及生存时间的关系。MGMF表达情况与患者无进展生存期及生存期的关系用Kaplan-meier生存曲线表示,并采用log-rank方法分析。结果患者性别、年龄、术前Karnofsky评分及Ki-67阳性率与无进展生存期和生存期无相关性(P＞0.05)。MGMT阳性率与无进展生存期呈负相关(r=0.074,P<0.05),与生存期呈负相关(r=-0.127,P＜0.001)。将所有患者分为MGMT指数≤15%和MGMT指数＞15% 2组,无进展生存期对比,差异有统计学意义(P＜0.05),生存期对比差异有统计学意义(P=0.001)。结论胶质瘤中Ki-67表达与肿瘤预后无关,MGMT表达与肿瘤预后有关,MGMT检测对胶质瘤预后判断可能有指导意义。

关键词: 胶质瘤, MGMT, Ki-67, 免疫组化

Abstract: Objective To study the expressions of O6-methylguanine-DNA methyltransferase(MGMT) and Ki-67 in glioma tissues and to evaluate the relationship between the expression of MGMT, Ki-67 and prognosis. Methods The gender, age, pre-operation Karnofsky performance status and progression-free survival time and overall survival time of 79 patients with gliomas were recorded, and then the expressions of Ki-67 and MGMT were tested by immunohistochemical technique for paraffin sections. Correlation of Ki-67 and MGMT with progression-free survival time and overall survival time was analyzed by multiple stepwise regression procedure. The comparision of Kaplan-meier survival curves of progression-free survival time and overall survival time according to MGMT expression was analyzed by log-rank method. Results No correlations were found among gender, age, pre-operation Karnofsky performance status and Ki-67 labeling index with progression-free survival time and overall survival time in the patients gliomas(P＞0.05). Negative correlation was confirmed between MGMT labeling index and progression-free survival time(r=0.074, P＜0.05), statistically significant correlation was also demonstrated between MGMT labeling index and overall survival time(r=-0.127, P＜0.001). According to MGMT labeling index, all patients were divided into two groups, MGMT labeling index ≤15% and MGMT labeling index ＞15%. Both progression-free survival time and overall survival time were significantly different between the two groups(P＜0.05 and P=0.001, respectively). Conclusion There was no correlation between Ki-67 antigen expression in glioma tissues and patient prognosis. MGMT expression in gliomas is correlated with patient progression-free survival time and overall survival time, so immunohistochemical assessment of MGMT may help predict patients' prognosis in clinical practice.

Key words: glioma, O6-methylguanine-DNA methyltransferase, Ki-67, immunohistochemistry

中图分类号:

R 739.4

徐丽;崔云;李桂林;江涛. 胶质瘤组织MGMT和Ki-67表达对患者预后的影响[J]. 首都医科大学学报, 2009, 30(3): 285-288.

XU Li;CUI Yun;LI Gui-lin;JIANG Tao. Association Between the Expression of O6-Methylguanine-DNA Methyltransferase and Ki-67 in Glioma Tissues and Prognosis of Patients with Glioma[J]. Journal of Capital Medical University, 2009, 30(3): 285-288.

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胶质瘤组织MGMT和Ki-67表达对患者预后的影响

Association Between the Expression of O6-Methylguanine-DNA Methyltransferase and Ki-67 in Glioma Tissues and Prognosis of Patients with Glioma

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