首都医科大学学报 ›› 2010, Vol. 31 ›› Issue (2): 268-271.

• 临床研究 • 上一篇    下一篇

老年高血压患者颈动脉粥样硬化与超敏C反应蛋白的关系

李晶玮*, 杜凤和, 徐秀英   

  1. 首都医科大学附属北京天坛医院心内科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-04-21 发布日期:2010-04-21
  • 通讯作者: 李晶玮

Analysis of Relationship between High-sensitivity C-reactive Protein and Carotid Atherosclerosis in Hypertensive Patients

LI Jing-wei*, DU Feng-he, XU Xiu-ying   

  1. Department of Cardiology, Beijing Tiantan Hospital, Capital Medical University
  • Received:1900-01-01 Revised:1900-01-01 Online:2010-04-21 Published:2010-04-21
  • Contact: LI Jing-wei

摘要:

目的 研究老年高血压病合并颈动脉粥样硬化的患者血清超敏C反应蛋白(highsensitivity C-reactive protein,hsCRP)的变化,探讨2者之间的相关性。方法 对首都医科大学附属北京天坛医院就诊的95例老年高血压患者进行颈动脉超声检查,测量颈总动脉内中膜厚度(intimalmedial thickness,IMT),观察有无颈动脉斑块形成,判断有无颈动脉粥样硬化,同时进行血清hsCRP浓度的测定。分析血清hsCRP与颈动脉粥样硬化、颈总动脉内中膜厚度及颈动脉斑块形成之间的关系。结果 合并颈动脉粥样硬化的老年高血压患者血清hsCRP明显高于无颈动脉硬化的老年高血压患者且差异有统计学意义(P=0.007)。结论 老年高血压病合并颈动脉粥样硬化尤其是颈动脉斑块患者的血清hsCRP显著高于无颈动脉病变者,说明血清hsCRP与老年高血压病患者颈动脉粥样硬化的发生有一定相关性,炎性反应可能参与了高血压病颈动脉粥样硬化的形成。

关键词: 高血压, 颈动脉疾病, 超敏C反应蛋白

Abstract:

Objective To study the relationship between serum high-sensitivity C-reactive protein(hsCRP) level and carotid atherosclerosis in elderly patients with essential hypertension. Methods The serum concentrations of high-sensitivity C-reactive protein(hsCRP) were measured in ninety-five elderly patients with essential hypertension. A color doppler ultrasound system was used to investigate the intimal-medial thickness(IMT) of common carotid artery(CCA) and the plaque of carotid artery. Results Serum hsCRP was significantly higher in the group with carotid atherosclerosis(CA) than in the group without CA〔(5.42±5.53) vs (2.78±3.22)mg/L, P=0.007〕. Conclusion Serum high-sensitivity C-reactive protein level is associated with carotid atherosclerosis in elderly patients with essential hypertension. Inflammatory response might play an important role in the pathogenesis of carotid atherosclerosis in patients with essential hypertension.

Key words: hypertension, carotid artery diseases, high sensitivity C reactive protein

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