关键词: 原发性高血压, 脉搏波速度, 肌酐清除率, 大动脉僵硬度

Abstract:

Objective To study the association between large arterial stiffness and creatinine clearance rate(Ccr) in patients with essential hypertension.
Methods Automatic pulse wave velocity(PWV) measuring system was applied to examine carotidfemoral PWV(CFPWV) as the parameter reflecting aortic arterial stiffness. 644 hypertensive patients aged 18~82 years(340 males and 304 females, mean age 52 years) with plasma creatinine<178 mmol/L were recruited in the study. Ccr was estimated by using the Cockcroft-Gault formula.
Results CFPWV increased gradually in patients with Ccr≥60 mL/min, 90 mL/min＞Ccr≥60 mL/min and Ccr＜60 mL/min(all P<0.01). CFPWV and Ccr were inversely and significantly correlated(P<0.001). A stepwise multiple regressive analysis demonstrated that CFPWV had significant independent influence on lower Ccr.
Conclusion Increased arterial stiffness occur in parallel with the decline in renal function in patients with essential hypertension, and which could reflect target organ damage of hypertension.

Key words: essential hypertension, pulse wave velocity, creatinine clearance rate, arterial stiffness