首都医科大学学报 ›› 2015, Vol. 36 ›› Issue (4): 645-648.doi: 10.3969/j.issn.1006-7795.2015.04.026

• 转化医学研究 • 上一篇    下一篇

痛泻要方对D-IBS结肠黏膜5-HT及CGA相关离子通道转运机制的研究

张声生, 杨成   

  1. 首都医科大学附属北京中医医院消化病诊疗中心, 北京 100010
  • 收稿日期:2012-02-11 出版日期:2015-08-21 发布日期:2015-07-17
  • 通讯作者: 张声生 E-mail:zhss2000@163.com
  • 基金资助:

    国家自然科学基金(81473644),北京市医院管理局临床医学发展专项经费资助(ZYLX201411),北京市卫生系统高层次卫生技术人才培养计划(2011-2-13)。

Effects of TongXie-YaoFang formula on serotonin and chromogranin a related transport mechanism of ion channels in colonic mucosa in diarrhea-predominant irritable bowel syndrome

Zhang Shengsheng, Yang Cheng   

  1. Center for Digestive Disease, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China
  • Received:2012-02-11 Online:2015-08-21 Published:2015-07-17
  • Supported by:

    This study was supported by National Natural Science Foundation of China(81473644), Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support(ZYLX201411), Project of Health Technical Personnel of Beijing Health System(2011-2-13).

摘要:

腹泻型肠易激综合征(diarrhea-predominant irritable bowel syndrome,D-IBS)是临床常见的功能性肠道疾病,给患者的生活和工作带来诸多不便。痛泻要方作为中医古代著名方剂,能够明显减轻D-IBS患者的腹痛、腹泻症状,提高其生活和工作质量,但其治疗的确切机制尚不明确,本文从5-羟色胺及嗜铬素A(chromogranin A,CGA)相关离子通道转运机制的角度出发,探讨痛泻要方对D-IBS结肠黏膜离子通道的影响,以期为后续的临床与基础研究提供可靠的依据。

关键词: 痛泻要方, 腹泻型肠易激综合征, 5-羟色胺, CGA, 离子通道, 结肠黏膜

Abstract:

Diarrhea-predominant irritable bowel syndrome(D-IBS) is a clinically common functional intestinal disease and it brings inconvenience to patients' live and work. TongXie-YaoFang(TXYF) formula, as a famous ancient prescription of Traditional Chinese Medicine, can significantly reduce the abdominal pain and diarrhea of D-IBS patients, thereby to improve the quality of their live and work. However, the exact mechanism is unclear. This article explores the influence of TXYF formula on ion channels of colon mucous membrane in D-IBS from the perspective of 5-HT and chromogranin A(CGA) related ion channel transport mechanism in order to provide reliable basis for subsequent clinical and basic research.

Key words: TongXie-YaoFang(TXYF) formula, diarrhea-predominant irritable bowel syndrome(D-IBS), serotonin(5-HT), chromogranin A, ion channels, colonic mucosa

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