浓缩生长因子联合骨代用品在上颌前牙区拔牙位点保存中的临床应用

doi:10.3969/j.issn.1006-7795.2017.03.023

首都医科大学学报 ›› 2017, Vol. 38 ›› Issue (3): 451-456.doi: 10.3969/j.issn.1006-7795.2017.03.023

浓缩生长因子联合骨代用品在上颌前牙区拔牙位点保存中的临床应用

蔺世晨¹, 段少宇¹, 朱静², 宋万红¹, 杨炼¹, 孙丹丹¹

1. 首都医科大学电力教学医院口腔科, 北京 100073;
2. 新华社门诊部口腔科, 北京 100031

收稿日期:2017-03-30 出版日期:2017-05-21 发布日期:2017-06-14
通讯作者: 段少宇 E-mail:dsy1@sohu.com
基金资助:
国家电网公司科学技术项目（SGHB000AJJS1400182）。

Clinical application of concentrate growth factors combined with bone substitute in site preservation of maxillary anterior region

Lin Shichen¹, Duan Shaoyu¹, Zhu Jing², Song Wanhong¹, Yang Lian¹, Sun Dandan¹

1. Department of Stomatology, Beijing Electric Power Hospital, Capital Medical University, Beijing 100073, China;
2. Department of Stomatology, Outpatient Department of Xinhua News Agency, Beijing 100031, China

Received:2017-03-30 Online:2017-05-21 Published:2017-06-14
Supported by:
This study was supported by Science and Technology Project of State Grid Corporation of China(SGHB000AJJS1400182).

摘要/Abstract

摘要： 目的评价使用浓缩生长因子（concentrate growth factors，CGF）联合Bio-oss骨粉在上颌前牙区进行拔牙位点保存的临床效果。方法选取需要拔除上颌前牙的病人26例共32颗牙，根据性别分层，采用数字表法随机分为2组，试验组（CGF组，16颗）拔牙窝内植入CGF和Bio-oss骨粉混合物，CGF膜关闭拔牙窝；对照组（自然愈合组，16颗）拔牙窝搔刮后放置止血海绵，待其自然愈合。病人于术后6个月时复诊，拍摄锥形束计算机断层扫描（cone beam computed tomography，CBCT），分别与术前CBCT比较，观察并测量拔牙位点牙槽骨高度和宽度的变化。结果在CGF组，唇、腭侧骨板高度术后6个月和术前相比，差异无统计学意义（P>0.05），牙槽嵴宽度术后6个月和术前相比，差异有统计学意义（P<0.05）；在对照组，唇、腭侧骨板高度和牙槽嵴宽度术后6个月和术前相比，差异均具有统计学意义（P<0.05）；2组间比较，唇、腭侧骨板高度和牙槽嵴宽度的变化差异有统计学意义（P<0.05）。结论 CGF联合Bio-oss骨粉进行拔牙位点保存可以有效地维持牙槽嵴的宽度和高度，为种植修复创造有利条件。

关键词: 拔牙位点保存, 浓缩生长因子, Bio-oss骨粉, 锥形束计算机断层扫描

Abstract: Objective To evaluate the clinical effect of site preservation by using concentrate growth factors (CGF) combined with Bio-oss bone powder in maxillary anterior region. Methods Thirty-two maxillary anterior teeth of 26 patients that should be extracted were randomly divided into two groups. For CGF group(16 cases), CGF combined with Bio-oss was implanted into teeth extraction socket, then covered the socket with CGF membrane; for control group(16 cases), teeth extraction socket was placed with hemostatic sponge after scoraping. Cone beam computed tomography (CBCT) should be taken after 6 months, then compared with preoperative, observed and measured the change of width and height of the alveolar bone at extraction site. Results In CGF group, the heights of labial and palatal bone plates between 6 months after surgery and preoperative were no statistically significant (P>0.05), and the widths between 6 months after surgery and preoperative were statistically significant (P<0.05). In control group, the heights of labial and palatal bone plates and the widths between 6 months after surgery and preoperative were statistically significant (P<0.05). The differences of changes between the two groups were statistically significant (P<0.05). Conclusion CGF combined with Bio-oss being used for preservation of teeth extraction site, which may effectively keep the width and height of alveolar ridge, it is favorable for implanting and repairing.

Key words: site preservation, concentrate growth factors(CGF), Bio-oss, cone beam computed tomography(CBCT)

中图分类号:

R782.11

蔺世晨, 段少宇, 朱静, 宋万红, 杨炼, 孙丹丹. 浓缩生长因子联合骨代用品在上颌前牙区拔牙位点保存中的临床应用[J]. 首都医科大学学报, 2017, 38(3): 451-456.

Lin Shichen, Duan Shaoyu, Zhu Jing, Song Wanhong, Yang Lian, Sun Dandan. Clinical application of concentrate growth factors combined with bone substitute in site preservation of maxillary anterior region[J]. Journal of Capital Medical University, 2017, 38(3): 451-456.

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浓缩生长因子联合骨代用品在上颌前牙区拔牙位点保存中的临床应用

Clinical application of concentrate growth factors combined with bone substitute in site preservation of maxillary anterior region

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