关键词: 肝硬化, 病因, 合并症, 构成比

Abstract: Objective To investigate the prevalence changes of aetiologies and complications of liver cirrhosis in northern China. Methods In this retrospective study, we identified cases of the demographic information and complications of patients with cirrhosis who were firstly hospitalized between December 31, 2013 to January 1, 2002. Two years were defined as a stage, to clarify the prevalence of the etiology of cirrhosis and complications in north China. Results Total 12 948 cirrhosis inpatients were included in this study during 12 years. Of them, male was accounted 69.02% and female 30.98%. The average age of all of the patients was (51.29±11.81) years (from7 to 93 year). Hepatitis B virus/hepatitis C virus (HBV/HCV) and alcoholic liver cirrhosis were most male, and autoimmune, drug-induced and non-alcoholic related cirrhosis were predominantly female. The hospitalized patients with cirrhosis were gradually increased. HBV related cirrhosis had fallen from 86.72% to 78.65% (P<0.01), however, HCV related cirrhosis had increased from 8.07% to 19.27% (P<0.01). The alcoholic, autoimmune and cryptogenic cirrhosis were respectively increased from 7.68% to 16.52%, from 2.65% to 10.0% and from 0.72% to 5.27% (P<0.01). The non-alcoholic fatty liver cirrhosis accounted for 3.76%. Ascites is the most common complication accounted for 66.34%, simple ascites and gastrointestinal bleeding constituent ratio decreased, while more than 2 complications increased in cirrhostic patients. Conclusion Hospitalized cirrhotic patients are increased. A significant increased constituent ratio of HCV, alcoholic, autoimmune and nonalcoholic cirrhosis are observed. The constituent ratio of ascites, gastrointestinal bleeding remained a major complication, are decreased.

Key words: liver cirrhosis, etiology, complications, composition ratio