关键词: 石珍安神颗粒, 精神分裂症前驱期, 认知损害

Abstract: Objective To investigate efficacy for Shi-zhen-an-shen (SZAS) granules on cognitive impairments in prodromal schizophrenia. Methods A total of 60 eligible participants were randomly assigned to either the treatment group or the control group in a ratio of 1∶1. The participants in the treatment group received SZAS and the placebo of aripiprazole, the control group received placebo of SZAS and aripiprazole. The treatment course had lasted for 4 weeks. Outcome measurements included Trail Making Test A (TMTA), Hopkins Verbal Learning Test-Revised (HVLT-R), Brief Visuospatial Memory Test Revised (BVMT-R),Continuous Performance Test (CPT), and Stroop Color-Word Test (SCWT). Results There were no significant group effects on all cognitive assessments between the two groups. The time effects on TMTA,HVLT-R,BVMT-R,Stroop-word test,SCWT and CPT showed significant differences between the two groups. The SCWT and CPT showed significant interactive effects. Further analysis indicated significant changes on all cognitive assessments in the treatment group after 4-weeks therapy in comparison with baseline, while only HVLT-R, BVMT-R, SCWT and CPT showed significant changes in the control group after 4-weeks treatment. Conclusion Compared with aripiprazole, the SZAS could improve cognitive impairment more widely. Longer time treatment may support that the SZAS is better than aripiprazole on improving cognitive impairments.

Key words: Shi-zhen-an-shen granules, prodromal schizophrenia, cognitive impairment