亚健康脾气虚证认知功能及社会功能的研究

doi:10.3969/j.issn.1006-7795.2024.03.012

首都医科大学学报 ›› 2024, Vol. 45 ›› Issue (3): 453-457.doi: 10.3969/j.issn.1006-7795.2024.03.012

亚健康脾气虚证认知功能及社会功能的研究

吴子遥^1,2, 冯思同^1,2, 董麟瑞^1,2, 郑思思^1,2, 宁艳哲^1,2, 贾竑晓^1,2*

1.首都医科大学附属北京安定医院国家精神疾病医学中心国家精神心理疾病临床医学研究中心精神疾病诊断与治疗北京市重点实验室，北京 100088；2.人脑保护高精尖创新中心，首都医科大学，北京 100069

收稿日期:2024-03-18 出版日期:2024-06-21 发布日期:2024-06-13
通讯作者: 贾竑晓 E-mail:jhxlj@ccmu.edu.cn
基金资助:
国家自然科学基金项目（82174311），北京中医药薪火传承“新3+3”工程示范案例项目(2023-ZYSF-19)。

Study of cognitive function and social function in the subhealthy people with spleen qi deficiency syndrome

Wu Ziyao1,2, Feng Sitong1,2,Dong Linrui1,2, Zheng Sisi1,2, Ning Yanzhe1,2, Jia Hongxiao1,2*

1.Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders Beijing Anding Hospital, Capital Medical University,Beijing 100088,China; 2. Advanced Innovation Center for Human Brain Protection, Capital Medical University,Beijing 100069,China

Received:2024-03-18 Online:2024-06-21 Published:2024-06-13
Supported by:
This study was supported by National Natural Science Foundation of China (82174311), Beijing Traditional Chinese Medicine Inheritance “New 3+3” Program Demonstration Case Project (2023-ZYSF-19).

摘要/Abstract

摘要： 目的初步探究亚健康脾气虚证受试者认知功能和社会功能的改变。方法纳入24例亚健康脾气虚证受试者和27例年龄、性别、受教育年限组间匹配的健康受试者。对所有受试者进行重复性成套神经心理状态测验、大体功能量表和脾气虚证亚健康中医证候积分表的评估，并进行统计学分析。结果与健康受试者相比，亚健康脾气虚证受试者的视觉广度分、注意分、延时记忆分、总分和大体功能量表得分明显降低（P<0.05）；而即刻记忆分、言语分组间差异无统计学意义（P>0.05）。相关性分析结果显示延时记忆分(r = －0.532，P = 0.009)及总分(r = －0.474，P = 0.022)与脾气虚证亚健康中医证候积分呈负相关性，延时记忆分(r = 0.564，P = 0.004)及总分(r = 0.785，P<0.001)与大体功能量表得分呈正相关。结论亚健康脾气虚证受试者的注意力、记忆力和视空间能力和社会功能受损，其中记忆力与脾气虚症状严重程度以及社会功能密切相关。本研究为从脾论治认知功能异常的相关疾病提供了实验依据，进一步丰富中医“脾藏意”理论内涵。

关键词: 脾气虚证, 亚健康, 认知功能, 社会功能, 脾藏意

Abstract: Objective To investigate on the change of cognitive function and social function in subhealthy people with spleen qi deficiency syndrome (SQDS). Methods Totally 24 subhealthy people with SQDS and 27 healthy people matched for age, gender, and education time were evaluated with Repeatable Battery for the Assessment of Neuropsychological Status(RBANS), Global Assessment of Functioning Scale(GAF) and Symptom of SQDS Scale. Results Compared with healthy controls, subhealthy people with SQDS showed significantly decreased scores in visuospatial index, attention index, delayed memory index, total scale and GAF(P<0.05), while scores differences in immediate memory index and language index were not statistically significant(P>0.05). Moreover, delayed memory index score(r=－0.532，P=0.009) and total scale score(r=－0.474，P=0.022) were negatively correlated with syndrome of SQDS scale score, but delayed memory index score(r=0.564，P= 0.004) and total scale score(r = 0.785，P<0.001) were positively correlated with GAF score. Conclusions The impairment of visuospatial ability, attention, memory and social function was observed in subhealthy people with SQDS, and poor memory was significantly associated with symptom of SQDS and social function. It provided experimental evidence for the treatment of dysfunctional cognition diseases from the viewpoint of traditional Chinese medicine theory of spleen and enriched the connotation of spleen stores yi.

Key words: spleen qi deficiency syndrome, subhealth, cognition function, social function, spleen stores yi

中图分类号:

R749

吴子遥, 冯思同, 董麟瑞, 郑思思, 宁艳哲, 贾竑晓. 亚健康脾气虚证认知功能及社会功能的研究[J]. 首都医科大学学报, 2024, 45(3): 453-457.

Wu Ziyao, Feng Sitong, Dong Linrui, Zheng Sisi, Ning Yanzhe, Jia Hongxiao. Study of cognitive function and social function in the subhealthy people with spleen qi deficiency syndrome[J]. Journal of Capital Medical University, 2024, 45(3): 453-457.

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亚健康脾气虚证认知功能及社会功能的研究

Study of cognitive function and social function in the subhealthy people with spleen qi deficiency syndrome

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