首都医科大学学报 ›› 2007, Vol. 28 ›› Issue (4): 519-521.

• 临床研究 • 上一篇    下一篇

睡眠呼吸暂停综合征合并高血压患者血压变化特点

刘志, 华琦, 朱宏旭, 李东宝   

  1. 首都医科大学宣武医院心内科
  • 收稿日期:2007-01-27 修回日期:1900-01-01 出版日期:2007-08-24 发布日期:2007-08-24
  • 通讯作者: 华琦

The Characteristics of Blood Pressure Variability in Patients with Hypertension and Obstructive Sleep Apnea

Liu Zhi, Hua Qi, Zhu Hongxu, Li Dongbao   

  1. Department of Cardiovascular, Xuanwu Hospital, Capital Medical University
  • Received:2007-01-27 Revised:1900-01-01 Online:2007-08-24 Published:2007-08-24

摘要: 目的 研究合并中重度阻塞性睡眠呼吸暂停综合征的高血压患者血压变化的特点,探讨其在心脑血管疾病发展中的作用。方法 94例研究对象根据诊所血压、24 h动态血压和多导睡眠图监测结果分为1)对照组(单纯高血压、轻度睡眠呼吸暂停综合征合并高血压,n=58),平均年龄(52±2.7)岁,体质量指数(27.2±0.98)kg/m2,2)实验组(中重度睡眠呼吸暂停综合征合并高血压,n=36),年龄平均(46±1.6)岁。体质量指数(28.2±0.48)kg/m2。比较2组睡眠呼吸暂停对血压变化的影响。结果 1)2组患者年龄、性别及体质量指数差异无统计学意义。实验组中非杓型血压(non-d ipper)的发生率为55.6%,明显高于对照组(22.4%)。2)实验组24 h、白天、夜间平均脉压差〔(49.57±13.27)mmHg(1 mmHg=0.133 kPa)、(49.53±12.92)mmHg、(50.31±16.86)mmHg〕明显高于对照组〔(44.69±7.12)mmHg、(45.12±7.50)mmHg、(42.69±6.28)mmHg〕,差异有统计学意义(P<0.05)。结论 中重度睡眠呼吸暂停影响血压昼夜节律的变化,对脉压也产生明显影响。

关键词: 高血压, 睡眠呼吸暂停, 血压昼夜节律, 脉压

Abstract: Objective To study the characteristics of blood pressure variability in the hypertensive patients with moderate or severe obstructive sleep apnea syndrom,which will help to reveal the causes of high morbidity of cardio-cerebral vasuclar events.Methods Ninety-four patients were divided into the control group(hypertension with mild obstructive sleep apnea,n=58,mean age(52±2.7)y, body mass index(27.3±0.98)kg/m2 and OSAS group(hypertension with moderate or severe OSAS,mean age(46±1.6)y,body mass index(28.2±0.48)kg/m2 according to the results of clinical blood pressure,24 h ambulatory blood pressure monitoring(ABP) and polysomnography(PSG).Results 1) The two groups are age,sex and body mass index matched.The rate of non-dipper profile in OSAS group(55.6%) is significantly higher than that of the control group(22.4%).2) Mean pulse pressure(PP) in 24 h,daytime and nighttime,in OSAS group((49.57±13.27)mmHg,(49.53±12.92)mmHg,(50.31±16.86)mmHg) is significantly higher than that of the control group((44.69±7.12)mmHg,(45.12±7.50)mmHg,(42.69±6.28)mmHg respectively)(P<0.05).Conclusion Moderate and severe OSAS affects the rhythm of blood pressure variability as well as does the pulse pressure.

Key words: hypertension, obstructive sleep apnea, blood pressure variability, pulse pressure

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