阿托伐他汀对自发性高血压大鼠主动脉活性氧、p22phox表达和SOD活性的影响

首都医科大学学报 ›› 2005, Vol. 26 ›› Issue (2): 116-119.

阿托伐他汀对自发性高血压大鼠主动脉活性氧、p22phox表达和SOD活性的影响

李卫萍, 孙明, 贾三庆

1. 首都医科大学附属北京友谊医院心血管疾病诊疗中心首都医科大学心脏病学系;2. 中南大学湘雅医院心血管内科

收稿日期:2005-03-04 修回日期:1900-01-01 出版日期:2005-04-24 发布日期:2005-04-24

Effects of Atorvastain on Reactive Oxygen Species, Expression of p22phox in Aorta and Level of Superoxide Dismutase of SHR

Li Weiping, Sun Ming, Jia Sanqing

1. Department of Heart and Vascular Center, Beijing Frendship Hospital, Capital University of Medical Sciences;2. Department of Cardiology, Capital University of Medical Sciences

Received:2005-03-04 Revised:1900-01-01 Online:2005-04-24 Published:2005-04-24

摘要/Abstract

摘要：

目的探讨自发性高血压大鼠(SHR)主动脉活性氧(ROS)和p22phoxmRNA表达、超氧化物歧化酶(SOD)活性的变化及相关性,并探讨阿托伐他汀治疗对上述指标的影响。方法以WKY大鼠为对照,观察给予SHR阿托伐他汀50mg/(kg·d)灌胃30d后,大鼠血压、血清SOD、一氧化氮(NO)、主动脉ROS含量以及p22phoxmRNA表达的变化。结果阿托伐他汀治疗30d后,SHR的血压、主动脉ROS含量及p22phoxmRNA表达下降,血清SOD、NO水平上升。主动脉ROS含量与p22phoxmRNA表达呈正相关,与SOD活性呈负相关。结论 p22phox亚单位表达上调和SOD活性降低是高血压血管ROS增多的重要机制。阿托伐他汀可下调p22phox亚单位表达和增加SOD活性,从而减少ROS。

关键词: 自发性高血压大鼠, 活性氧, p22phox, 超氧化物歧化酶, 阿托伐他汀

Abstract:

Objective The study was to investigate the alterations and the correlations among reactive oxygen species(ROS), p22phox mRNA expression, and activity of superoxide dismutase(SOD) in aorta of SHRand effects of atorvastain. Methods Wistar-Kyoto(WKY) rats were used as control, SHR were treated with atorvastain 〔50 mg/(kg·d)〕 for 30 days. Blood pressure, levels of serum SOD, nitric oxide(NO), ROS and p22phox mRNA expression in aorta were measured. Results After 30 days' treatment with atorvastain, blood pressure, levels of vascular ROS, and mRNA expression of p22phox in aorta decreased and the levels of serum SOD and NOincreased significantly. Aortic ROS was positively correlated with p22phox mRNA expression and negatively correlated with SOD. Conclusion The increased genesis of aortic ROS in SHRis caused by upregulation of p22phox mRNA expression and reduction of SOD. Atorvastain can reduce ROSby down regulating p22phox expression and increasing SOD.

Key words: spontaneously hypertensive rats, reactive oxygen species, p22phox, superoxide dismutase, atorvastain

中图分类号:

R541.7⁺5

李卫萍;孙明;贾三庆. 阿托伐他汀对自发性高血压大鼠主动脉活性氧、p22phox表达和SOD活性的影响[J]. 首都医科大学学报, 2005, 26(2): 116-119.

Li Weiping;Sun Ming;Jia Sanqing . Effects of Atorvastain on Reactive Oxygen Species, Expression of p22phox in Aorta and Level of Superoxide Dismutase of SHR[J]. Journal of Capital Medical University, 2005, 26(2): 116-119.

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