Cocktail探针药物评价姜黄对肝细胞色素P450酶的影响

首都医科大学学报 ›› 2004, Vol. 25 ›› Issue (4): 427-430.

Cocktail探针药物评价姜黄对肝细胞色素P₄₅₀酶的影响

扈金萍, 闫淑莲, 唐静成, 张锦楠

首都医科大学基础医学院化学药理系

收稿日期:2003-08-20 修回日期:1900-01-01 出版日期:2004-10-15 发布日期:2004-10-15
通讯作者: 张锦楠

Simultaneous Evaluation of Effect of Rhizoma Curcumae Longae on Hepatic CYP₄₅₀ by Cocktail Probe Drugs

Hu Jinping, Yan Shulian, Tang Jingcheng, Zhang Jinnan

Department of Chemical Pharmacology, Capital University of Medical Sciences

Received:2003-08-20 Revised:1900-01-01 Online:2004-10-15 Published:2004-10-15

摘要/Abstract

摘要： 用Cocktail探针药物法,研究姜黄对大鼠肝细胞P₄₅₀(CYP₄₅₀)的影响.将SD雄性大鼠分组,给予姜黄的水提物,以生理盐水组为空白对照,以苯巴比妥组为阳性对照,通过HPLC检测Cocktail探针药物的代谢率来评价各组的CYP₄₅₀.结果:给予姜黄组的大鼠CYP1A2和CYP2E1的水平显著低于对照组,CYP3A4的水平没有显著变化.表明:姜黄对大鼠CYP1A2和CYP2E1有抑制作用,但对大鼠CYP3A4的影响不显著.

关键词: Cocktail, CYP₄₅₀, 咖啡因, 氨苯砜, 氯唑沙宗, 探针药物, 姜黄

Abstract: The aim was to study the change of the rat hepatic CYP 450 content following administration of Rhizoma Curcumae Longae by cocktail probe drugs. Rats were randomly divided into groups. One group of rats received Rhizoma Curcumae Longae plant extracts once daily orally for six days. The rats in another group received once daily orally normal saline as blank control group and phenobarbital as positive control group at the same time. The plasma concentration of cocktail probe drugs was determined by HPLC. The CYP1A2 and CYP2E1 content of the groups of rats received Rhizoma Curcumae Longae plant extracts was reduced, but the CYP3A4 content didn't markedly change. It suggests that Rhizoma Curcumae Longae is inhibitor of the CYP1A2 and CYP2E1, but the CYP3A4 can be hardly affected.

Key words: Cocktail, CYP₄₅₀, caffeine, dapsone, chlorzoxazone, probe drugs, Rhizoma Curcumae Longae

中图分类号:

R285.5
Q554

扈金萍;闫淑莲;唐静成;张锦楠. Cocktail探针药物评价姜黄对肝细胞色素P₄₅₀酶的影响[J]. 首都医科大学学报, 2004, 25(4): 427-430.

Hu Jinping;Yan Shulian;Tang Jingcheng;Zhang Jinnan. Simultaneous Evaluation of Effect of Rhizoma Curcumae Longae on Hepatic CYP₄₅₀ by Cocktail Probe Drugs[J]. Journal of Capital Medical University, 2004, 25(4): 427-430.

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Cocktail探针药物评价姜黄对肝细胞色素P₄₅₀酶的影响

Simultaneous Evaluation of Effect of Rhizoma Curcumae Longae on Hepatic CYP₄₅₀ by Cocktail Probe Drugs

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