首都医科大学学报 ›› 2014, Vol. 35 ›› Issue (4): 496-500.doi: 10.3969/j.issn.1006-7795.2014.04.023

• 临床研究 • 上一篇    下一篇

新生儿轮状病毒感染临床特点分析

王艳1, 李云娟1, 王雷2   

  1. 1. 北京新世纪儿童医院内科病房, 北京 100045;
    2. 首都医科大学附属北京儿童医院重症监护室, 北京 100045
  • 收稿日期:2013-07-28 出版日期:2014-08-21 发布日期:2014-07-22
  • 通讯作者: 李云娟 E-mail:yunjuan.li@mail.ncich.com.cn

Clinical analysis of the newborn rotavirus infection

Wang Yan1, Li Yunjuan1, Wang Lei2   

  1. 1. Internal Medicine, Beijing New Century Children's Hospital, Beijing 100045, China;
    2. Intensive Care Unit, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China
  • Received:2013-07-28 Online:2014-08-21 Published:2014-07-22

摘要:

目的 分析轮状病毒(rotavirus, RV)感染新生儿临床数据,认识新生儿RV感染的特点,以早期发现、避免误诊,避免不必要的抗生素应用,防止新生儿病房医院感染扩散。方法 回顾分析2009年1月至2012年1月102例1岁以内轮状病毒感染住院患儿的临床资料,分为新生儿组和婴儿组,比较2组患儿的体温、发热天数、呕吐及腹泻次数、血气分析中的碱剩余(base excess,BE);并将新生儿组中以“败血症?”收入院的患儿与同期确诊严重细菌感染的新生儿进行分析,比较其白细胞总数(white blood cell,WBC)及C反应蛋白(C reactive protein,CRP)。结果 新生儿组和婴儿组比较,2组患儿大多均有发热,但新生儿多为低热,发热时间短,而婴儿多为高热,发热时间相对较长,且新生儿呕吐及腹泻次数均较婴儿少,血气分析BE值下降不明显,两组比较差异具有统计学意义;新生儿组中以“败血症?”收入院的患儿与同期确诊严重细菌感染的新生儿比较,2组患儿病初WBC总数及CRP值差异无统计学意义,但发病24 h后复查则严重细菌感染组WBC总数及CRP值较轮状病毒组高,差异具有统计学意义,尤以CRP值差异更为显著。结论 新生儿RV感染与婴儿比较多表现为短程低热,典型消化道症状轻微,部分新生儿有精神减弱、纳奶少、皮肤发花、末梢循环略差等败血症样表现,常以“新生儿败血症?”收入院,易误诊,与严重细菌感染新生儿不同之处为热程24 h后白细胞总数及CRP值无进行性增高。

关键词: 婴儿, 新生儿, 轮状病毒感染, 败血症

Abstract:

Objective To analyze clinical data of rotavirus infection in the newborn and realize the characteristics of rotavirus infection of the newborn, in order to discover early and avoid diagnostic errors and avoid using the unwanted antibiotics, to prevent hospital infection diffusion of newborn nursery. Methods To analyze retrospectively 102 clinical data of the children who were smaller than one years old and in our hospital because of rotavirus infection from January, 2009 to January, 2012. They were divided into newborn group and infant group. We contrasted their temperatures and fever days and vomiting times and diarrhea times and base excess(BE) in blood gas analysis. Then, we would analyze the newborns who were in hospital because of "septicaemia?" and the newborns who were diagnosed bacteria infection severely at the corresponding time period, in order to contrast their white blood cell(WBC) and C reactive protein(CRP). Results Comparison of newborn group and infant group, The both group children had fever mostly, but the most newborns had low-grade fever and fever time were short, however, the most infants had high-grade fever and fever time were longer. The newborn's vomiting and diarrhea times were fewer than those of the infants, and the BE descending were not obvious. Comparison results of the two groups has statistical significance. Comparison of the newborn who were in hospital because of "septicaemia?" and the newborn who were diagnosed bacteria infection severely at the corresponding time period, At the initial stage of the disease, the comparison results of the WBC and CRP had no statistical significance, but after 24 hours, the newborn who were diagnosed bacteria infection severely had higher WBC and CRP, the comparison results had statistical significance, especially, the difference of CRP are notable. Conclusion The newborns who have rotavirus infection show low-grade and short-range fever, however, typical digestive symptom is light. Some newborns have weak spirit and bad appetite, skin bloom and bad distal circulation, so they often are in hospital because of "septicaemia?" and are diagnosed by mistake easily. The difference of the newborns who have rotavirus infection and the newborns who were diagnosed bacteria infection severely is that WBC and CRP do not raise up progressively after 24 hours of disease of rotavirus infection.

Key words: infant, new life, rotavirus infection, septicaemia

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