关键词: 肝源性糖尿病, 糖化血清白蛋白, 糖化血红蛋白, 空腹血糖

Abstract: Objective To compare the abnormal metabolism of glucose(fasting blood glucose, FBG; hemoglobin A1c, HbA1c and glycated albumin, GA) of patients with hepatogenic diabetes(HD) and patients with liver cirrhosis(LC), to estimate their significances in evaluating hepatogenic diabetes carbohydrate metabolic disturbance.
Methods Eighty-one patients from Beijing Youan Hospital were enrolled in this study, among whom 27 had definite diagnosis of hepatogenic diabetes and 54 patients with liver cirrhosis were enrolled into control group. Clinical data of the patients were collected during hospitalization, blood-test of FBG, HbA1c, GA were obtained in the next morning of admission.
Results GA and HbA1c in patients with hepatogenic diabetes were significantly higher than those of patients with cirrhosis(P<0.01). In the hepatogenic diabetes group, FBG was higher than 7.0 mmol/L in 18 cases(accounting for 66.7%), HbA1c greater than 6.5% in 96 cases(accounting for 22.2%); GA was higher than 16.87% in 25 cases(accounting for 92.6%). In cirrhosis group, FBG was higher than 7.0 mmol/L in 2 cases(accounting for 3.7%), HbA1c was higher than 6.5% in 1 case(accounting for 1.85% ), GA was higher than 16.87% in 14 cases(accounting for 25.9%).
Conclusion FBG and HbA1c had a high specificity in hepatogenic diabetes monitoring, but had a low sensitivity. While GA had a high sensitivity and low specificity. It would be more helpful when combining GA, FBG and HbA1c in hepatogenic diabetes monitoring.

Key words: hepatogenic diabetes, glycated albumin, glycosylated hemoglobin, fasting blood glucose